Monocytes and macrophages provide the first line of defense against pathogens. They also
initiate acquired immunity by processing and presenting antigens and provide the …

Traditional biomedical models are easy to manage in experimental facilities and allow fast
and affordable basic genetic studies related to human disorders, but in some cases they do …

Background The specialisation of mammalian cells in time and space requires genes
associated with specific pathways and functions to be co-ordinately expressed. Here we …

The immune composition of the tumor microenvironment regulates processes including
angiogenesis, metastasis, and the response to drugs or immunotherapy. To facilitate the …

Physiological and molecular similarities between organisms make it possible to translate
findings from simpler experimental systems—model organisms—into more complex ones …

The human population is growing, and as a result we need to produce more food whilst
reducing the impact of farming on the environment. Selective breeding and genomic …

Over the last few years, we have seen an increasing interest and demand for pigs in
biomedical research. Domestic pigs (Sus scrofa domesticus) are closely related to humans …

The gut microbiota makes important contributions to host immune system development and
resistance to pathogen infections, especially during early life. However, studies addressing …

The F4/80 antigen, encoded by the Adgre1 locus, has been widely-used as a monocyte-
macrophage marker in mice, but its value as a macrophage marker in other species is …

Sheep are a key source of meat, milk and fibre for the global livestock sector, and an
important biomedical model. Global analysis of gene expression across multiple tissues has …