Mesenchymal stromal/stem cell (MSC)-derived exosomes in clinical trials
A Lotfy, NM AboQuella, H Wang - Stem Cell Research & Therapy, 2023 - Springer
Mesenchymal stromal/stem cells (MSCs) are widely utilized in cell therapy because of their
robust immunomodulatory and regenerative properties. Their paracrine activity is one of the …
robust immunomodulatory and regenerative properties. Their paracrine activity is one of the …
Mesenchymal stem cell-derived exosomes for clinical use
M Mendt, K Rezvani, E Shpall - Bone marrow transplantation, 2019 - nature.com
Mesenchymal stem/stromal cells (MSCs) are commonly used as a source of cellular therapy
due to their strong immunosuppressive and regenerative effects. One of the key …
due to their strong immunosuppressive and regenerative effects. One of the key …
MSC exosomes mediate cartilage repair by enhancing proliferation, attenuating apoptosis and modulating immune reactivity
Mesenchymal stem cell (MSC) exosome was previously shown to be effective in repairing
critical size osteochondral defects in an immunocompetent rat model. Here we investigate …
critical size osteochondral defects in an immunocompetent rat model. Here we investigate …
Bone marrow mesenchymal stem cell-derived exosomes protect cartilage damage and relieve knee osteoarthritis pain in a rat model of osteoarthritis
L He, T He, J **ng, Q Zhou, L Fan, C Liu… - Stem cell research & …, 2020 - Springer
Background This study aimed to investigate the effect of bone marrow mesenchymal stem
cell (BMSC)-derived exosome injection on cartilage damage and pain relief in both in vitro …
cell (BMSC)-derived exosome injection on cartilage damage and pain relief in both in vitro …
Exosomes-loaded thermosensitive hydrogels for corneal epithelium and stroma regeneration
Corneal damage forms scar tissue and manifests as permanent corneal opacity, which is the
main cause of visual impairment caused by corneal diseases. To treat these diseases …
main cause of visual impairment caused by corneal diseases. To treat these diseases …
MSC exosomes alleviate temporomandibular joint osteoarthritis by attenuating inflammation and restoring matrix homeostasis
The efficacy of mesenchymal stem cell (MSC) therapies is increasingly attributed to
paracrine secretion, particularly exosomes. In this study, we investigated the role of MSC …
paracrine secretion, particularly exosomes. In this study, we investigated the role of MSC …
Mesenchymal stem cell-derived exosomes as a new therapeutic strategy for liver diseases
The administration of mesenchymal stem cells (MSCs) as a therapy for liver disease holds
great promise. MSCs can differentiate into hepatocytes, reduce liver inflammation, promote …
great promise. MSCs can differentiate into hepatocytes, reduce liver inflammation, promote …
Paracrine mechanisms of mesenchymal stem cell-based therapy: current status and perspectives
Mesenchymal stem cells (MSCs) are one of a few stem cell types to be applied in clinical
practice as therapeutic agents for immunomodulation and ischemic tissue repair. In addition …
practice as therapeutic agents for immunomodulation and ischemic tissue repair. In addition …
[HTML][HTML] Exosomes derived from mesenchymal stem cells
B Yu, X Zhang, X Li - International journal of molecular sciences, 2014 - mdpi.com
The functional mechanisms of mesenchymal stem cells (MSCs) have become a research
focus in recent years. Accumulating evidence supports the notion that MSCs act in a …
focus in recent years. Accumulating evidence supports the notion that MSCs act in a …
Biomaterials functionalized with MSC secreted extracellular vesicles and soluble factors for tissue regeneration
The therapeutic benefits of mesenchymal stromal cell (MSC) transplantation are attributed to
their secreted factors, including extracellular vesicles (EVs) and soluble factors. The …
their secreted factors, including extracellular vesicles (EVs) and soluble factors. The …