Mesenchymal stromal/stem cell (MSC)-derived exosomes in clinical trials

A Lotfy, NM AboQuella, H Wang - Stem Cell Research & Therapy, 2023 - Springer
Mesenchymal stromal/stem cells (MSCs) are widely utilized in cell therapy because of their
robust immunomodulatory and regenerative properties. Their paracrine activity is one of the …

Mesenchymal stem cell-derived exosomes for clinical use

M Mendt, K Rezvani, E Shpall - Bone marrow transplantation, 2019 - nature.com
Mesenchymal stem/stromal cells (MSCs) are commonly used as a source of cellular therapy
due to their strong immunosuppressive and regenerative effects. One of the key …

MSC exosomes mediate cartilage repair by enhancing proliferation, attenuating apoptosis and modulating immune reactivity

S Zhang, SJ Chuah, RC Lai, JHP Hui, SK Lim, WS Toh - Biomaterials, 2018 - Elsevier
Mesenchymal stem cell (MSC) exosome was previously shown to be effective in repairing
critical size osteochondral defects in an immunocompetent rat model. Here we investigate …

Bone marrow mesenchymal stem cell-derived exosomes protect cartilage damage and relieve knee osteoarthritis pain in a rat model of osteoarthritis

L He, T He, J **ng, Q Zhou, L Fan, C Liu… - Stem cell research & …, 2020 - Springer
Background This study aimed to investigate the effect of bone marrow mesenchymal stem
cell (BMSC)-derived exosome injection on cartilage damage and pain relief in both in vitro …

Exosomes-loaded thermosensitive hydrogels for corneal epithelium and stroma regeneration

Q Tang, B Lu, J He, X Chen, Q Fu, H Han, C Luo, H Yin… - Biomaterials, 2022 - Elsevier
Corneal damage forms scar tissue and manifests as permanent corneal opacity, which is the
main cause of visual impairment caused by corneal diseases. To treat these diseases …

MSC exosomes alleviate temporomandibular joint osteoarthritis by attenuating inflammation and restoring matrix homeostasis

S Zhang, KYW Teo, SJ Chuah, RC Lai, SK Lim… - Biomaterials, 2019 - Elsevier
The efficacy of mesenchymal stem cell (MSC) therapies is increasingly attributed to
paracrine secretion, particularly exosomes. In this study, we investigated the role of MSC …

Mesenchymal stem cell-derived exosomes as a new therapeutic strategy for liver diseases

G Lou, Z Chen, M Zheng, Y Liu - Experimental & molecular medicine, 2017 - nature.com
The administration of mesenchymal stem cells (MSCs) as a therapy for liver disease holds
great promise. MSCs can differentiate into hepatocytes, reduce liver inflammation, promote …

Paracrine mechanisms of mesenchymal stem cell-based therapy: current status and perspectives

X Liang, Y Ding, Y Zhang, HF Tse… - Cell …, 2014 - journals.sagepub.com
Mesenchymal stem cells (MSCs) are one of a few stem cell types to be applied in clinical
practice as therapeutic agents for immunomodulation and ischemic tissue repair. In addition …

[HTML][HTML] Exosomes derived from mesenchymal stem cells

B Yu, X Zhang, X Li - International journal of molecular sciences, 2014 - mdpi.com
The functional mechanisms of mesenchymal stem cells (MSCs) have become a research
focus in recent years. Accumulating evidence supports the notion that MSCs act in a …

Biomaterials functionalized with MSC secreted extracellular vesicles and soluble factors for tissue regeneration

MÁ Brennan, P Layrolle… - Advanced functional …, 2020 - Wiley Online Library
The therapeutic benefits of mesenchymal stromal cell (MSC) transplantation are attributed to
their secreted factors, including extracellular vesicles (EVs) and soluble factors. The …