Summary" Pan-coronavirus" antivirals targeting conserved viral components can be
designed. Here, we show that the rationally engineered H84T-banana lectin (H84T …

The interactions between biomolecules and material interfaces at the molecular level are
complicated but very important for the development of materials science, nanotechnology …

For over 20 years there has been immense biological insight gained using single molecule
mechanical measurements to understand properties of biomolecules. This review outlines …

The measuring tip of an atomic force microscope (AFM) can be upgraded to a specific
biosensor by attaching one or a few biomolecules to the apex of the tip. The …

New SARS‐CoV‐2 variants are continuously emerging with critical implications for therapies
or vaccinations. The 22 N‐glycan sites of Spike remain highly conserved among SARS‐CoV …

Binding of antibodies to their cognate antigens is fundamental for adaptive immunity.
Molecular engineering of antibodies for therapeutic and diagnostic purposes emerges to be …

Von Willebrand factor (VWF) plays a central role in hemostasis. Triggered by shear-stress, it
adheres to platelets at sites of vascular injury. Inactivation of VWF has been associated to …

Activation of membrane receptors through clustering is a common mechanism found in
various biological systems. Spatial proximity of receptors may be transduced across the …

The binding of ligands to receptors within a nanoscale small space is relevant in biology,
biosensing, and affinity filtration. Binding in confinement can be studied with biological …

Traditional monoclonal antibodies such as Trastuzumab encounter limitations when treating
Human Epidermal Growth Factor Receptor 2 (HER2)-positive breast cancer, particularly in …