The study of homologous recombination has its historical roots in meiosis. In this context,
recombination occurs as a programmed event that culminates in the formation of crossovers …

In most organisms, genome haploidization requires reciprocal DNA exchanges (crossovers)
between replicated parental homologs to form bivalent chromosomes. These are resolved to …

Crossing-over ensures accurate chromosome segregation during meiosis, and every pair of
chromosomes obtains at least one crossover, even though the majority of recombination …

Cohesin is an evolutionary conserved multi‐protein complex that plays a pivotal role in
chromosome dynamics. It plays a role both in sister chromatid cohesion and in establishing …

Crossover recombination facilitates the accurate segregation of homologous chromosomes
during meiosis,. In mammals, poorly characterized regulatory processes ensure that every …

The kinetochore is the crucial apparatus regulating chromosome segregation in mitosis and
meiosis. Particularly in meiosis I, unlike in mitosis, sister kinetochores are captured by …

During mitosis, replicated chromosomes (sister chromatids) become attached at the
kinetochore by spindle microtubules emanating from opposite poles and segregate …

During meiosis, repair of programmed DNA double-strand breaks (DSBs) by recombination
promotes pairing of homologous chromosomes and their connection by crossovers. Two …

BACKGROUND Meiotic chromosome segregation in human oocytes is notoriously error-
prone, especially with ageing. Such errors markedly reduce the reproductive chances of …

Homologous chromosome segregation errors during meiosis I are common and generate
aneuploid embryos. Here, we provide a reason for this susceptibility to mis-segregation by …