The alterations of mitochondrial DNA in coronary heart disease

H Hu, Y Lin, X Xu, S Lin, X Chen, S Wang - Experimental and molecular …, 2020 - Elsevier
Coronary heart disease (CHD) is the major cause of death in modern society. CHD is
characterized by atherosclerosis, which could lead to vascular cavity stenosis or obstruction …

Comprehensive molecular analysis of 61 Egyptian families with hereditary nonsyndromic hearing loss

BS Budde, MA Aly, MR Mohamed, A Breß… - Clinical …, 2020 - Wiley Online Library
Nonsyndromic hearing loss is an extremely heterogeneous disorder. Thus, clinical
diagnostics is challenging, in particular due to differences in the etiology of hearing loss …

Review and research gap identification in genetics causes of syndromic and nonsyndromic hearing loss in Saudi Arabia

F Almalki - Annals of Human Genetics, 2024 - Wiley Online Library
Congenital hearing loss is one of the most common sensory disabilities worldwide. The
genetic causes of hearing loss account for 50% of hearing loss. Genetic causes of hearing …

Gentamicin extended interval regimen and ototoxicity in neonates

N Mohamed, RIH Ismail, AAA Ibrahim - International journal of pediatric …, 2015 - Elsevier
Objectives To assess the extended interval regimen gentamicin associated ototoxicity in
neonatal intensive care unit using hearing tests. Methods Two hundred and twenty neonates …

Genetic epidemiology of mitochondrial pathogenic variants causing nonsyndromic hearing loss in a large cohort of South Indian hearing impaired individuals

M Subathra, A Ramesh, M Selvakumari… - Annals of Human …, 2016 - Wiley Online Library
Mitochondria play a critical role in the generation of metabolic energy in the form of ATP.
Tissues and organs that are highly dependent on aerobic metabolism are involved in …

Molecular and Clinical Characterization of a Cohort of Autosomal Recessive Sensorineural Hearing Loss in Egyptian Patients

MM Sayed-Ahmed, HT El-Bassyouni, HH Afifi… - Journal of Molecular …, 2024 - Springer
Hearing loss (HL) is one of the most common health problems worldwide. Autosomal
recessive non-syndromic sensorineural hearing loss (ARNSHL) represents a large portion …

Frequency of mitochondrial m. 1555A> G mutation in Syrian patients with non-syndromic hearing impairment

H Kaheel, A Breß, MA Hassan, AA Shah… - BMC Ear, Nose and …, 2018 - Springer
Background Mitochondrial maternally inherited hearing impairment (HI) appears to be
increasing in frequency. The incidence of mitochondrial defects causing HI is estimated to …

Mitochondrial mutations in non-syndromic hearing loss at UAE

WKE Mohamed, M Arnoux, THS Cardoso… - International Journal of …, 2020 - Elsevier
Introduction Hearing loss (HL) is a common sensory disorder over the world, and it has been
estimated that genetic etiology is involved in more than 50% of the cases in developed …

Molecular diagnosis of mtDNA syndromes in Egyptian pediatric patients: a hospital-based study

D Mehaney, D Abaas, W Sayed, M Sharawy… - Egyptian Journal of …, 2024 - Springer
Background MCDs, or mitochondrial disorders, are a major contributor to morbidity and
mortality. There are few studies on the prevalence of gene mutations in pediatric MCD …

Pharmacogenetic screening of A1555G and C1494T mitochondrial mutations and the use of ototoxic drugs among Jordanians.

A Yehya, B Al-Trad, M Bani-Hmoud… - European Review for …, 2021 - search.ebscohost.com
OBJECTIVE: Hearing loss may impact an individual's psychosocial behaviors and lead to
cognitive decline. The goals of this study were to describe the frequency of nonsyndromic …