Kinetochores are molecular machines that power chromosome segregation during the
mitotic and meiotic cell divisions of all eukaryotes. Aristotle explains how we think we have …

A critical requirement for mitosis is the distribution of genetic material to the two daughter
cells. The central player in this process is the macromolecular kinetochore structure, which …

Microtubule (MT) filaments, composed of α/β-tubulin dimers, are fundamental to cellular
architecture, function and organismal development. They are nucleated from MT organizing …

We have developed a computer software package, IMOD, as a tool for analyzing and
viewing three-dimensional biological image data. IMOD is useful for studying and modeling …

Kinetochores are macromolecular machines that couple chromosomes to dynamic
microtubule tips during cell division, thereby generating force to segregate the …

The cyclin dependent kinase Cdk1 controls the cell cycle, which is best understood in the
model organism S. cerevisiae. Research performed during the past decade has significantly …

In eukaryotes, accurate chromosome segregation in mitosis and meiosis maintains genome
stability and prevents aneuploidy. Kinetochores are large protein complexes that, by …

Nucleus-vacuole (NV) junctions in Saccharomyces cerevisiae are formed through specific
interactions between Vac8p on the vacuole membrane and Nvj1p in the nuclear envelope …

We used electron tomography to examine microtubules (MTs) growing from pure tubulin in
vitro as well as two classes of MTs growing in cells from six species. The tips of all these …

For over a century, scientists have strived to understand the mechanisms that govern the
accurate segregation of chromosomes during mitosis. The most intriguing feature of this …