Obesity is characterized by increased storage of fatty acids in an expanded adipose tissue
mass and is closely associated with the development of insulin resistance in peripheral …

Insulin resistance is a hallmark of type 2 diabetes mellitus and is associated with a metabolic
and cardiovascular cluster of disorders (dyslipidaemia, hypertension, obesity [especially …

Adipose tissue is now recognized as an important endocrine organ, capable of secreting a
large number of endocrine factors which regulate a wide variety of physiological functions …

Adiponectin is an adipokine that is specifically and abundantly expressed in adipose tissue
and directly sensitizes the body to insulin. Hypoadiponectinemia, caused by interactions of …

Metabolic syndrome is thought to result from obesity and obesity-linked insulin resistance.
Obesity in adulthood is characterized by adipocyte hypertrophy. Adipose tissue participates …

Adiponectin is a fat-derived hormone whose reduction plays central roles in obesity-linked
diseases including insulin resistance/type 2 diabetes and atherosclerosis. The cloning of …

Obesity is associated with an array of health problems in adult and pediatric populations.
Understanding the pathogenesis of obesity and its metabolic sequelae has advanced …

Background Caloric restriction without malnutrition extends life span in a range of organisms
including insects and mammals and lowers free radical production by the mitochondria …

Adiponectin is an adipocyte‐derived hormone that was discovered in 1995. Unlike leptin,
which was identified around the same time, the clinical relevance of adiponectin remained …

Adiponectin is a recently described adipokine that has been recognized as a key regulator
of insulin sensitivity and tissue inflammation. It is produced by adipose tissue (white and …