Despite advances in uncovering the mechanisms that underlie neuroinflammation and
neurodegenerative disease, therapies that prevent neuronal loss remain elusive. Targeting …

Neuroglia critically shape the brain´ s response to ischemic stroke. However, their
phenotypic heterogeneity impedes a holistic understanding of the cellular composition of the …

The central nervous system's limited capacity for regeneration often leads to permanent
neuronal loss following injury. Reprogramming resident reactive astrocytes into induced …

Microglia and astrocytes play an important role in the neuroinflammatory response and
contribute to both the destruction of neighboring tissue as well as the resolution of …

The central nervous system (CNS) comprises a diverse range of brain cell types with distinct
functions and gene expression profiles. Although single-cell RNA sequencing (scRNA-seq) …

In this study, we examined how systemic inflammation affects repair of brain injury. To this
end, we created a brain-injury model by stereotaxic injection of ATP, a damage-associated …

Microglia and astrocytes play an important role in the neuroinflammatory response and
contribute to both the destruction of neighboring tissue as well as the resolution of …

Human teeth are highly innervated organs that contain a variety of mesenchymal stem cell
populations that could be used for cell-based regenerative therapies. Specific molecules are …

While stroke represents one of the main causes of death worldwide, available effective drug
treatment options remain limited to classic thrombolysis with recombinant tissue …

Human umbilical cord mesenchymal stem cells (hUCMSC) have shown promising potential
in ameliorating brain injury, but the mechanism is unclear. We explore the role of …