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Ageing and rejuvenation of tissue stem cells and their niches
Most adult organs contain regenerative stem cells, often organized in specific niches. Stem
cell function is critical for tissue homeostasis and repair upon injury, and it is dependent on …
cell function is critical for tissue homeostasis and repair upon injury, and it is dependent on …
Formation and integration of new neurons in the adult hippocampus
Neural stem cells (NSCs) generate new neurons throughout life in the mammalian brain.
Adult-born neurons shape brain function, and endogenous NSCs could potentially be …
Adult-born neurons shape brain function, and endogenous NSCs could potentially be …
[HTML][HTML] Adult hippocampal neurogenesis in aging and Alzheimer's disease
Cognitive deficits associated with Alzheimer's disease (AD) severely impact daily life for the
millions of affected individuals. Progressive memory impairment in AD patients is associated …
millions of affected individuals. Progressive memory impairment in AD patients is associated …
Aging and rejuvenation of neural stem cells and their niches
Aging has a profound and devastating effect on the brain. Old age is accompanied by
declining cognitive function and enhanced risk of brain diseases, including cancer and …
declining cognitive function and enhanced risk of brain diseases, including cancer and …
[HTML][HTML] Protein interaction networks in neurodegenerative diseases: From physiological function to aggregation
The accumulation of protein inclusions is linked to many neurodegenerative diseases that
typically develop in older individuals, due to a combination of genetic and environmental …
typically develop in older individuals, due to a combination of genetic and environmental …
J-domain protein chaperone circuits in proteostasis and disease
The J-domain proteins (JDP) form the largest protein family among cellular chaperones. In
cooperation with the Hsp70 chaperone system, these co-chaperones orchestrate a plethora …
cooperation with the Hsp70 chaperone system, these co-chaperones orchestrate a plethora …
The landscape of molecular chaperones across human tissues reveals a layered architecture of core and variable chaperones
The sensitivity of the protein-folding environment to chaperone disruption can be highly
tissue-specific. Yet, the organization of the chaperone system across physiological human …
tissue-specific. Yet, the organization of the chaperone system across physiological human …
[HTML][HTML] NAD+ boosting reduces age-associated amyloidosis and restores mitochondrial homeostasis in muscle
Aging is characterized by loss of proteostasis and mitochondrial homeostasis. Here, we
provide bioinformatic evidence of dysregulation of mitochondrial and proteostasis pathways …
provide bioinformatic evidence of dysregulation of mitochondrial and proteostasis pathways …
DNAJB6, a key factor in neuronal sensitivity to amyloidogenesis
CAG-repeat expansions in at least eight different genes cause neurodegeneration. The
length of the extended polyglutamine stretches in the corresponding proteins is …
length of the extended polyglutamine stretches in the corresponding proteins is …
Epigenetic aging in adult neurogenesis
Neural stem cells (NSCs) in the hippocampus generate new neurons throughout life, which
functionally contribute to cognitive flexibility and mood regulation. Yet adult hippocampal …
functionally contribute to cognitive flexibility and mood regulation. Yet adult hippocampal …