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Important roles of dietary taurine, creatine, carnosine, anserine and 4-hydroxyproline in human nutrition and health
Taurine (a sulfur-containing β-amino acid), creatine (a metabolite of arginine, glycine and
methionine), carnosine (a dipeptide; β-alanyl-l-histidine), and 4-hydroxyproline (an imino …
methionine), carnosine (a dipeptide; β-alanyl-l-histidine), and 4-hydroxyproline (an imino …
[HTML][HTML] Physiology and pathophysiology of carnosine
Abstract Carnosine (β-alanyl-l-histidine) was discovered in 1900 as an abundant non-
protein nitrogen-containing compound of meat. The dipeptide is not only found in skeletal …
protein nitrogen-containing compound of meat. The dipeptide is not only found in skeletal …
Protective effects of apigenin and myricetin against cisplatin-induced nephrotoxicity in mice
Context: Currently, the outcomes of the use of cisplatin in cancer therapy is limited by
nephrotoxicity. Objective: This study aims to investigate the nephroprotective role of …
nephrotoxicity. Objective: This study aims to investigate the nephroprotective role of …
Therapeutic potential of carnosine and its derivatives in the treatment of human diseases
Despite significant progress in the pathogenesis, diagnosis, treatment, and prevention of
cancer and neurodegenerative diseases, their occurrence and mortality are still high around …
cancer and neurodegenerative diseases, their occurrence and mortality are still high around …
Carnosic acid attenuates renal injury in an experimental model of rat cisplatin-induced nephrotoxicity
Nephrotoxicity is one of the serious dose limiting side effects of cisplatin when used in the
treatment of various malignant conditions. Accumulating evidence suggests that oxidative …
treatment of various malignant conditions. Accumulating evidence suggests that oxidative …
[HTML][HTML] Icariin ameliorates cisplatin-induced cytotoxicity in human embryonic kidney 293 cells by suppressing ROS-mediated PI3K/Akt pathway
Cisplatin, as an effective chemotherapeutic agent, is widely used to treat verious types of
cancers. Nephrotoxicity induced by cisplatin seriously limits its clinical application. Icariin, a …
cancers. Nephrotoxicity induced by cisplatin seriously limits its clinical application. Icariin, a …
Carnosine and cancer: a perspective
The application of carnosine in medicine has been discussed since several years, but many
claims of therapeutic effects have not been substantiated by rigorous experimental …
claims of therapeutic effects have not been substantiated by rigorous experimental …
Antioxidant and protective effect of Stachys pilifera Benth against nephrotoxicity induced by cisplatin in rats
The aim of current study was to assess the antioxidant and renoprotective effects of Stachys
pilifera Benth (SPB) hydroalcoholic extract on nephrotoxicity induced with cisplatin (CP) …
pilifera Benth (SPB) hydroalcoholic extract on nephrotoxicity induced with cisplatin (CP) …
The footprints of mitochondrial impairment and cellular energy crisis in the pathogenesis of xenobiotics-induced nephrotoxicity, serum electrolytes imbalance, and …
Fanconi's Syndrome (FS) is a disorder characterized by impaired renal proximal tubule
function. FS is associated with a vast defect in the renal reabsorption of several chemicals …
function. FS is associated with a vast defect in the renal reabsorption of several chemicals …
Carnosine ameliorates liver fibrosis and hyperammonemia in cirrhotic rats
Aim Chronic liver injury and cirrhosis leads to liver failure. Hyperammonemia is a
deleterious consequence of liver failure. On the other hand, oxidative stress seems to play a …
deleterious consequence of liver failure. On the other hand, oxidative stress seems to play a …