In eukaryotic cells, protein sorting is a highly regulated mechanism important for many
physiological events. After synthesis in the endoplasmic reticulum and trafficking to the Golgi …

In recent decades, many sphingolipid enzymes, sphingolipid‐metabolism regulators and
sphingolipid transfer proteins have been isolated and characterized. This review will provide …

Phosphatidylinositol 4-kinases (PI4Ks) regulate vesicle-mediated export from the Golgi
apparatus via phosphatidylinositol 4-phosphate (PtdIns4P) binding effector proteins that …

Protein kinase D (PKD) mediates the actions of stimuli that promote diacylglycerol (DAG)
biogenesis. By phosphorylating effectors that regulate transcription, fission and polarized …

Protein kinase D is a family of evolutionarily conserved serine/threonine kinases that
belongs to the Ca++/Calmodulin-dependent kinase superfamily. Signal transduction …

Membrane-bound transport carriers are used to transfer cargo between membranes of the
secretory and the endocytic pathways. The generation of these carriers can be classified into …

The Golgi functions principally in the biogenesis and trafficking of glycoproteins and lipids. It
is compartmentalized into multiple flattened adherent membrane sacs termed cisternae …

Lipids are amphiphilic molecules that self-assemble to form biological membranes.
Thousands of lipid species coexist in the cell and, once combined, define organelle identity …

Proper Golgi complex function depends on the activity of Arf1, a GTPase whose effectors
assemble and transport outgoing vesicles. Phosphatidylinositol 4-phosphate (PI4P) …

Lipids are unevenly distributed within and between cell membranes, thus defining organelle
identity. Such distribution relies on local metabolic branches and mechanisms that move …