Insects transmit the causative agents for such debilitating diseases as malaria, lymphatic
filariases, slee** sickness, Chagas' disease, leishmaniasis, river blindness, Dengue, and …

Oxidative stress is considered causal of aging and pathological cell death, however, very
little is known about its function in the natural processes that support the formation of an …

Recent works have shown the importance of reduction/oxidation (redox) regulation in
various biological phenomena. Thioredoxin (TRX) is one of the major components of the …

The disulfide reducing enzymes glutathione reductase and thioredoxin reductase are highly
conserved among bacteria, fungi, worms, and mammals. These proteins maintain …

Background Sexual dimorphism results in the formation of two types of individuals with
specialized reproductive roles and is most evident in the germ cells and gonads. Results We …

Reactive oxygen species (ROS), mostly derived from mitochondrial activity, can damage
various macromolecules and consequently cause cell death. This ROS activity has been …

Breast and ovarian cancers are among the 10 leading cancer types in females with
mortalities of 15% and 6%, respectively. Despite tremendous efforts to conquer malignant …

Cells maintain a reduced intracellular state in the face of a highly oxidizing extracellular
environment. Redox signalling pathways provide a link between external stimuli, through the …

Mild impairment of mitochondrial function has been shown to increase lifespan in genetic
model organisms including worms, flies and mice. To better understand the mechanisms …

The transition from oocyte to embryo marks the onset of development. This process requires
complex regulation to link developmental signals with profound changes in mRNA …