Sigma-1 receptor (S1R) is a multi-functional, ligand-operated protein situated in
endoplasmic reticulum (ER) membranes and changes in its function and/or expression have …

The sigma-1 receptor (Sig-1R) is an endoplasmic reticulum (ER) protein that resides
specifically in the mitochondria-associated endoplasmic reticulum (ER) membrane (MAM) …

The target of rapamycin (TOR) is a highly conserved protein kinase and a central controller
of growth. Mammalian TOR complex 2 (mTORC2) regulates AGC kinase family members …

Background: FUN14 domain containing 1 (FUNDC1) is a highly conserved outer
mitochondrial membrane protein. The aim of this study is to examine whether FUNDC1 …

Autophagy is a self‐digestive process that degrades intracellular components, including
damaged organelles, to maintain energy homeostasis and to cope with cellular stress …

The σ 1 and σ 2 receptors are enigmatic proteins that have attracted attention for decades
due to the chemical diversity and therapeutic potential of their ligands. However, despite …

Steroidogenesis begins with cellular internalization of low-density lipoprotein particles and
subsequent intracellular processing of cholesterol. Disorders in these steps include …

The Sigma 1 receptor (Sigmar1) is a ubiquitously expressed multifunctional inter-organelle
signaling chaperone protein playing a diverse role in cellular survival. Recessive mutation in …

The endoplasmic reticulum (ER) and mitochondria communicate via contact sites known as
mitochondria-associated ER membranes or MAM. The region has emerged as the primary …

All animal subcellular membranes require cholesterol, which influences membrane fluidity
and permeability, fission and fusion processes, and membrane protein function. The …