In addition to the canonical double helix, DNA can fold into various other inter-and
intramolecular secondary structures. Although many such structures were long thought to be …

Guanine-rich DNA strands can fold in vitro into non-canonical DNA structures called G-
quadruplexes. These structures may be very stable under physiological conditions …

Critical evidence for the biological relevance of G-quadruplexes (G4) has recently been
obtained in seminal studies performed in a variety of organisms. Four-stranded G …

Guanine (G)-rich sequences in nucleic acids can assemble into G-quadruplex structures that
involve G-quartets linked by loop nucleotides. The structural and topological diversity of G …

Summary The GGGGCC (G4C2) intronic repeat expansion within C9ORF72 is the most
common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia …

We introduce RNA G-quadruplex sequencing (rG4-seq), a transcriptome-wide RNA G-
quadruplex (rG4) profiling method that couples rG4-mediated reverse transcriptase stalling …

Abstract G-quadruplexes (G4s) are non-classical DNA or RNA secondary structures that
have been first observed decades ago. Over the years, these four-stranded structural motifs …

Much of the mammalian genome is transcribed, generating long non-coding RNAs
(lncRNAs) that can undergo post-transcriptional surveillance whereby only a subset of the …

INTRODUCTION Many cellular RNAs contain regions that fold into stable structures required
for function. Both Watson− Crick and noncanonical interactions can play important roles in …

An emerging body of evidence indicates that post-transcriptional gene regulation relies not
only on the sequence of mRNAs but also on their folding into intricate secondary structures …