A probabilistic approach to extreme statistics of Brownian escape times in dimensions 1, 2, and 3

SD Lawley, JB Madrid - Journal of Nonlinear Science, 2020 - Springer
First passage time (FPT) theory is often used to estimate timescales in cellular and
molecular biology. While the overwhelming majority of studies have focused on the time it …

[HTML][HTML] First passage time distribution of multiple impatient particles with reversible binding

SD Lawley, JB Madrid - The Journal of chemical physics, 2019 - pubs.aip.org
Consider N independently diffusing particles that reversibly bind to a target. We study a
problem recently introduced by Grebenkov of finding the first passage time (FPT) for K of the …

How receptor surface diffusion and cell rotation increase association rates

SD Lawley, CE Miles - SIAM Journal on Applied Mathematics, 2019 - SIAM
Many biological processes are initiated when diffusing extracellular reactants reach
receptors on a cell membrane. Calculating this arrival rate has therefore attracted theoretical …

Investigating the ability of astrocytes to drive neural network synchrony

G Handy, A Borisyuk - PLoS computational biology, 2023 - journals.plos.org
Recent experimental works have implicated astrocytes as a significant cell type underlying
several neuronal processes in the mammalian brain, from encoding sensory information to …

Revising Berg-Purcell for finite receptor kinetics

G Handy, SD Lawley - Biophysical journal, 2021 - cell.com
From nutrient uptake to chemoreception to synaptic transmission, many systems in cell
biology depend on molecules diffusing and binding to membrane receptors. Mathematical …

The effects of fast inactivation on conditional first passage times of mortal diffusive searchers

SD Lawley - SIAM Journal on Applied Mathematics, 2021 - SIAM
The first time a searcher finds a target is called a first passage time (FPT). In many physical,
chemical, and biological processes, the searcher is “mortal,” which means that the searcher …

Extending mathematical frameworks to investigate neuronal dynamics in the presence of microglial ensheathment

N Garcia, G Handy - bioRxiv, 2024 - biorxiv.org
Recent experimental evidence has shown that glial cells, including microglia and astrocytes,
can ensheathe synapses, positioning them to disrupt neurotransmitter flow between pre-and …

Intransitiveness: from games to random walks

A Baldi, F Bagnoli - Future Internet, 2020 - mdpi.com
Many games in which chance plays a role can be simulated as a random walk over a graph
of possible configurations of board pieces, cards, dice or coins. The end of the game …

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SD Lawley, JB Madrid