Resistance to therapeutic treatment and metastatic progression jointly determine a fatal
outcome of cancer. Cancer metastasis and therapeutic resistance are traditionally studied as …

Metastasis is the primary cause of cancer morbidity and mortality. The process involves a
complex interplay between intrinsic tumor cell properties as well as interactions between …

Mesenchymal stem cells (MSCs) are promising candidates for adult cell therapies in
regenerative medicine. To fully exert their potential, efficient homing and migration toward …

Integrins are transmembrane receptors that have been implicated in the biology of various
human physiological and pathological processes. These molecules facilitate cell …

In their roles as major adhesion receptors, integrins signal across the plasma membrane in
both directions. Recent structural and cell biological data suggest models for how integrins …

Thoracic aortic diseases that involve progressive enlargement, acute dissection, or rupture
are influenced by the hemodynamic loads and mechanical properties of the wall. We have …

Cells in their in vivo microenvironment constantly encounter and respond to a multitude of
signals. While the role of biochemical signals has long been appreciated, the importance of …

Correlative clinical evidence and experimental observations indicate that integrin adhesion
receptors, in particular those of the αV family, are relevant to cancer cell features, including …

We describe an approach to manipulate and measure mechanical interactions between
cells and their underlying substrates by using microfabricated arrays of elastomeric …

Cell adhesions mediate important bidirectional interactions between cells and the
extracellular matrix. They provide an interactive interface between the extracellular chemical …