Cognitive function and variability in antipsychotic drug–naive patients with first-episode psychosis: a systematic review and meta-analysis
Importance Cognitive impairment contributes significantly to clinical outcome and level of
function in individuals with psychotic disorders. These impairments are present already at …
function in individuals with psychotic disorders. These impairments are present already at …
[HTML][HTML] Lifespan evolution of neurocognitive impairment in schizophrenia-A narrative review
Cognitive impairment is a well-recognized key feature of schizophrenia. Here we review the
evidence on (1) the onset and sensitive periods of change in cognitive impairment before …
evidence on (1) the onset and sensitive periods of change in cognitive impairment before …
Cognitive impairment in schizophrenia: relationships with cortical thickness in fronto-temporal regions, and dissociability from symptom severity
Cognitive impairments are a core and persistent characteristic of schizophrenia with
implications for daily functioning. These show only limited response to antipsychotic …
implications for daily functioning. These show only limited response to antipsychotic …
[HTML][HTML] A new era for schizophrenia drug development–Lessons for the future
KT Granger, M Sand, S Caswell… - Drug Discovery …, 2023 - Elsevier
Highlights•Drugs for schizophrenia are often based on dopamine blockade and have
serious side-effects.•Xanomeline/trospium may well herald the first non-dopamine based …
serious side-effects.•Xanomeline/trospium may well herald the first non-dopamine based …
Childhood trauma, brain structure and emotion recognition in patients with schizophrenia and healthy participants
Childhood trauma, and in particular physical neglect, has been repeatedly associated with
lower performance on measures of social cognition (eg emotion recognition tasks) in both …
lower performance on measures of social cognition (eg emotion recognition tasks) in both …
Factors impacting access and engagement of cognitive remediation therapy for people with schizophrenia: a systematic review
Objectives Neurocognitive deficits are central in schizophrenia. Cognitive remediation has
proven effective in alleviating these deficits, with medium effect sizes. However, sizeable …
proven effective in alleviating these deficits, with medium effect sizes. However, sizeable …
[HTML][HTML] Cognitive and inflammatory heterogeneity in severe mental illness: Translating findings from blood to brain
Recent findings link cognitive impairment and inflammatory-immune dysregulation in
schizophrenia (SZ) and bipolar (BD) spectrum disorders. However, heterogeneity and …
schizophrenia (SZ) and bipolar (BD) spectrum disorders. However, heterogeneity and …
Cognitive heterogeneity across schizophrenia and bipolar disorder: a cluster analysis of intellectual trajectories
Objective: Cognitive dysfunction cut across diagnostic categories and is present in both
schizophrenia and bipolar disorder, although with considerable heterogeneity in both …
schizophrenia and bipolar disorder, although with considerable heterogeneity in both …
Intra-and inter-individual cognitive variability in schizophrenia and bipolar spectrum disorder: an investigation across multiple cognitive domains
There is substantial cognitive heterogeneity among patients with schizophrenia (SZ) and
bipolar disorders (BD). More knowledge about the magnitude and clinical correlates of …
bipolar disorders (BD). More knowledge about the magnitude and clinical correlates of …
Effects of socioeconomic status in cognition of people with schizophrenia: results from a Latin American collaboration network with 1175 subjects
BackgroundCognition heavily relies on social determinants and genetic background. Latin
America comprises approximately 8% of the global population and faces unique challenges …
America comprises approximately 8% of the global population and faces unique challenges …