NF-κB pathway consists of canonical and non-canonical pathways. The canonical NF-κB is
activated by various stimuli, transducing a quick but transient transcriptional activity, to …

Marginal-Zone Lymphomas The third most common lymphoma, MZL is usually indolent and
often a consequence of chronic antigenic stimulation from a pathogen such as Helicobacter …

Chronic lymphocytic leukaemia (CLL), the most frequent type of leukaemia in adults, is a
lymphoproliferative disorder that is characterized by the expansion of monoclonal, mature …

Ubiquitination is a highly conserved and fundamental posttranslational modification (PTM) in
all eukaryotes regulating thousands of proteins. The RING (really interesting new gene) …

Background The evasion from apoptosis is a common strategy adopted by most tumors, and
inhibitors of apoptosis proteins (IAPs) are among the most studied molecular and …

Recent investigations have provided an increasingly complete picture of the genetic
landscape of chronic lymphocytic leukaemia (CLL). These analyses revealed that the CLL …

Follicular lymphoma (FL) is an indolent disease, but 30%–40% of cases undergo histologic
transformation to an aggressive malignancy, typically represented by diffuse large B cell …

Noncanonical NF-κB signaling differs from canonical NF-κB signaling by being activated
through different cell surface receptors, cytoplasmic adaptors, and NF-κB dimers. Under …

Mantle cell lymphoma (MCL) is an aggressive tumor, but a subset of patients may follow an
indolent clinical course. To understand the mechanisms underlying this biological …

The genetic basis for Waldenström macroglobulinemia (WM) remains to be clarified.
Although 6q losses are commonly present, recurring gene losses in this region remain to be …