Pathogenesis of allergic diseases and implications for therapeutic interventions

J Wang, Y Zhou, H Zhang, L Hu, J Liu, L Wang… - Signal transduction and …, 2023 - nature.com
Allergic diseases such as allergic rhinitis (AR), allergic asthma (AAS), atopic dermatitis (AD),
food allergy (FA), and eczema are systemic diseases caused by an impaired immune …

Gut-microbiota-derived metabolites maintain gut and systemic immune homeostasis

J Wang, N Zhu, X Su, Y Gao, R Yang - Cells, 2023 - mdpi.com
The gut microbiota, including bacteria, archaea, fungi, viruses and phages, inhabits the
gastrointestinal tract. This commensal microbiota can contribute to the regulation of host …

Dietary fiber and SCFAs in the regulation of mucosal immunity

JK Tan, L Macia, CR Mackay - Journal of allergy and clinical immunology, 2023 - Elsevier
Gut bacterial metabolites such as short-chain fatty acids (SCFAs) have important effects on
immune cells and the gut. SCFAs derive from the fermentation of dietary fiber by gut …

Short chain fatty acids: Microbial metabolites for gut-brain axis signalling

KJ O'Riordan, MK Collins, GM Moloney… - Molecular and Cellular …, 2022 - Elsevier
The role of the intestinal microbiota as a regulator of gut-brain axis signalling has risen to
prominence in recent years. Understanding the relationship between the gut microbiota, the …

[HTML][HTML] Microbial regulation of host physiology by short-chain fatty acids

B van der Hee, JM Wells - Trends in microbiology, 2021 - cell.com
Our ancestral diet consisted of much more nondigestible fiber than that of many societies
today. Thus, from an evolutionary perspective the human genome and its physiological and …

The immunomodulatory functions of butyrate

MT Siddiqui, GAM Cresci - Journal of inflammation research, 2021 - Taylor & Francis
The gastrointestinal (GI) system contains many different types of immune cells, making it a
key immune organ system in the human body. In the last decade, our knowledge has …

The role of short-chain fatty acids in the interplay between gut microbiota and diet in cardio-metabolic health

A Nogal, AM Valdes, C Menni - Gut microbes, 2021 - Taylor & Francis
The gut microbiota plays an important role in cardio-metabolic diseases with diet being
among the strongest modulators of gut microbiota composition and function. Resistant …

Gut microbiota-derived metabolites in the regulation of host immune responses and immune-related inflammatory diseases

W Yang, Y Cong - Cellular & molecular immunology, 2021 - nature.com
The gut microbiota has a critical role in the maintenance of immune homeostasis. Alterations
in the intestinal microbiota and gut microbiota-derived metabolites have been recognized in …

Short-chain fatty acid receptors and gut microbiota as therapeutic targets in metabolic, immune, and neurological diseases

T Ikeda, A Nishida, M Yamano, I Kimura - Pharmacology & therapeutics, 2022 - Elsevier
Dysbiosis is associated with various diseases. The composition and diversity of gut
microbiota affect host physiology through the production of bioactive metabolites. Short …

The role of short-chain fatty acids in immunity, inflammation and metabolism

Y Yao, X Cai, W Fei, Y Ye, M Zhao… - Critical reviews in food …, 2022 - Taylor & Francis
Short-chain fatty acids (SCFAs) are carboxylic acids with carbon atom numbers less than 6,
which are important metabolites of gut microbiome. Existing research shows that SCFAs …