The role of inflammation in perinatal brain injury
Inflammation is increasingly recognized as being a critical contributor to both normal
development and injury outcome in the immature brain. The focus of this Review is to …
development and injury outcome in the immature brain. The focus of this Review is to …
New horizons for newborn brain protection: enhancing endogenous neuroprotection
KJ Hassell, M Ezzati, D Alonso-Alconada… - Archives of Disease in …, 2015 - fn.bmj.com
Intrapartum-related events are the third leading cause of childhood mortality worldwide and
result in one million neurodisabled survivors each year. Infants exposed to a perinatal insult …
result in one million neurodisabled survivors each year. Infants exposed to a perinatal insult …
Therapeutic hypothermia for neonatal hypoxic–ischemic encephalopathy–where to from here?
JO Davidson, G Wassink, LG Van den Heuij… - Frontiers in …, 2015 - frontiersin.org
Hypoxia–ischemia before or around the time of birth occurs in approximately 2/1000 live
births and is associated with a high risk of death or lifelong disability. Therapeutic …
births and is associated with a high risk of death or lifelong disability. Therapeutic …
[HTML][HTML] Melatonin and the circadian system: contributions to successful female reproduction
Objective To summarize the role of melatonin and circadian rhythms in determining optimal
female reproductive physiology, especially at the peripheral level. Design Databases were …
female reproductive physiology, especially at the peripheral level. Design Databases were …
Improving pregnancy outcomes in humans through studies in sheep
JL Morrison, MJ Berry, KJ Botting… - American Journal …, 2018 - journals.physiology.org
Experimental studies that are relevant to human pregnancy rely on the selection of
appropriate animal models as an important element in experimental design. Consideration …
appropriate animal models as an important element in experimental design. Consideration …
Role of melatonin in embryo fetal development
SE Voiculescu, N Zygouropoulos… - Journal of medicine …, 2014 - pmc.ncbi.nlm.nih.gov
Melatonin is an indoleamine produced by the pineal gland and secreted in a circadian
manner. In the past few decades, research over this topic has been enhanced. Melatonin …
manner. In the past few decades, research over this topic has been enhanced. Melatonin …
Novel interventions to reduce oxidative-stress related brain injury in neonatal asphyxia
AL Solevåg, GM Schmölzer, PY Cheung - Free Radical Biology and …, 2019 - Elsevier
Perinatal asphyxia-induced brain injury may present as hypoxic-ischemic encephalopathy in
the neonatal period, and disability including cerebral palsy in the long term. The brain injury …
the neonatal period, and disability including cerebral palsy in the long term. The brain injury …
Antenatal antioxidant treatment with melatonin to decrease newborn neurodevelopmental deficits and brain injury caused by fetal growth restriction
Fetal intrauterine growth restriction (IUGR) is a serious pregnancy complication associated
with increased rates of perinatal morbidity and mortality, and ultimately with long‐term …
with increased rates of perinatal morbidity and mortality, and ultimately with long‐term …
Oxidative stress‐mediated aging during the fetal and perinatal periods
L Marseglia, G D'Angelo, S Manti… - Oxidative Medicine …, 2014 - Wiley Online Library
Oxidative stress is worldwide recognized as a fundamental component of the aging, a
process that begins before birth. There is a critical balance between free radical generation …
process that begins before birth. There is a critical balance between free radical generation …
Perinatal compromise affects development, form, and function of the hippocampus part one; clinical studies
TA White, SL Miller, AE Sutherland, BJ Allison… - Pediatric …, 2024 - nature.com
The hippocampus is a neuron-rich specialised brain structure that plays a central role in the
regulation of emotions, learning and memory, cognition, spatial navigation, and motivational …
regulation of emotions, learning and memory, cognition, spatial navigation, and motivational …