Space radiation biology for “Living in Space”

S Furukawa, A Nagamatsu, M Nenoi… - BioMed Research …, 2020 - Wiley Online Library
Space travel has advanced significantly over the last six decades with astronauts spending
up to 6 months at the International Space Station. Nonetheless, the living environment while …

The effects of real and simulated microgravity on cellular mitochondrial function

HP Nguyen, PH Tran, KS Kim, SG Yang - npj Microgravity, 2021 - nature.com
Astronauts returning from space shuttle missions or the International Space Station have
been diagnosed with various health problems such as bone demineralization, muscle …

Modeling the impact of microgravity at the cellular level: implications for human disease

P Bradbury, H Wu, JU Choi, AE Rowan… - Frontiers in cell and …, 2020 - frontiersin.org
A lack of gravity experienced during space flight has been shown to have profound effects
on human physiology including muscle atrophy, reductions in bone density and immune …

Role of apoptosis in wound healing and apoptosis alterations in microgravity

S Riwaldt, TJ Corydon, D Pantalone… - … in bioengineering and …, 2021 - frontiersin.org
Functioning as the outermost self-renewing protective layer of the human organism, skin
protects against a multitude of harmful biological and physical stimuli. Consisting of …

Simulated microgravity triggers DNA damage and mitochondria-mediated apoptosis through ROS generation in human promyelocytic leukemic cells

R Singh, M Rajput, RP Singh - Mitochondrion, 2021 - Elsevier
The weightlessness or microgravity, a physical factor in space, may adversely affect the
health of the space travellers or astronauts. The knowledge about the effect of microgravity …

Mitochondrial stress in the spaceflight environment

AM Rudolf, WR Hood - Mitochondrion, 2024 - Elsevier
Abstract Space is a challenging environment that deregulates individual homeostasis. The
main external hazards associated with spaceflight include ionizing space radiation …

Effects of simulated Microgravity in Vitro on Human Metaphase II oocytes: an Electron Microscopy-based study

S Miglietta, L Cristiano, MSB Espinola, MG Masiello… - Cells, 2023 - mdpi.com
Highlights What are the main findings? For the first time, the in vitro effects of simulated
microgravity using a Random Positioning Machine on the ultrastructural features of human …

Omics studies of tumor cells under microgravity conditions

J Graf, H Schulz, M Wehland, TJ Corydon… - International Journal of …, 2024 - mdpi.com
Cancer is defined as a group of diseases characterized by abnormal cell growth, expansion,
and progression with metastasis. Various signaling pathways are involved in its …

[HTML][HTML] Exploration of space to achieve scientific breakthroughs

B Prasad, P Richter, N Vadakedath, R Mancinelli… - Biotechnology …, 2020 - Elsevier
Living organisms adapt to changing environments using their amazing flexibility to remodel
themselves by a process called evolution. Environmental stress causes selective pressure …

Simulated microgravity reduces quality of ovarian follicles and oocytes by disrupting communications of follicle cells

K Cheng, X Feng, C Yang, C Ma, S Niu, L Jia, X Yang… - npj …, 2023 - nature.com
Ovarian follicles are the fundamental structures that support oocyte development, and
communications between oocytes and follicle somatic cells are crucial for oogenesis …