Cardiotonic steroids (CTS), long used to treat heart failure, are endogenously produced in
mammals. Among them are the hydrophilic cardenolide ouabain and the more hydrophobic …

Excess dietary salt is a major cause of hypertension. Nevertheless, the specific mechanisms
by which salt increases arterial constriction and peripheral vascular resistance, and thereby …

Cardiac glycosides have been used for decades to treat congestive heart failure. The recent
identification of cardiotonic steroids such as ouabain, digoxin, marinobufagenin, and …

BACKGROUND An endogenous digitalis-like compound in mammals has long been
postulated, but only recently has a substance indistinguishable from ouabain been identified …

Recent reports have shown the presence of a ouabain-like inhibitor of Na+/K (+)-ATPase in
humans. We have purified a bovine hypothalamic Na+/K (+)-ATPase inhibitory factor (HIF) …

The sodium pump (Na/K‐ATPase) is a plasma membrane enzyme that transports Na+ and
K+ against their physiological gradients in most eukaryotic cells. Besides pum** ions, the …

A critical question in hypertension research is: How is long-term blood pressure controlled?
Excessive NaCl ingestion or NaCl retention by the kidneys and the consequent tendency …

Many patients with essential hypertension (EH) exhibit increased left ventricular mass.
Similarly, elevated circulating levels of an endogenous ouabainlike factor (OLF) have been …

Pre-eclampsia (preE) is a multifaceted complication found uniquely in the pregnant patient
and one that has puzzled scientists for years. PreE is not a single disorder, but a complex …

In previous reports, we described the isolation and characterization of an endogenous
digitalislike factor (EDLF). In this report, we describe a unique combination of bioassay and …