Infectious diseases are the second most important cause of human death worldwide;
Staphylococcus aureus (S. aureus) is a very common human pathogenic microorganism that …

Five-membered heterocycles are essential structural components in various antibacterial
drugs; the physicochemical properties of a five-membered heterocycle can play a crucial …

Chirality plays an important role in the development of many pharmaceuticals, being a
general property of 'handedness'; nevertheless, a large number of pharmaceuticals are still …

Staphylococcus aureus is one of the leading hospital-associated and community-associated
pathogens, which has caused a global public health concern. The emergence of methicillin …

Lower Urinary Tract Symptoms (LUTS) are frequently present in the general population as
patients age with approximately a third of individuals experiencing LUTS during their …

Introduction: Linezolid is an oxazolidinone antibiotic that is active against drug-resistant
Gram-positive bacteria and multidrug-resistant Mycobacterium tuberculosis. Real-world …

Vancomycin-resistant enterococci infections are of great public health significance due to
limited therapeutic options. We investigated epidemiological trends and risk factors of …

Antimicrobial peptides (AMPs), as well as host defense peptides (HDPs), constitute the first
line of defense as part of the innate immune system. Humans are known to express …

Due to the long-term and widespread use of antibiotics in clinic, the problem of bacterial
resistance is increasingly serious, and the development of new drugs to treat drug-resistant …

Currently, the efficacy of antibiotics is severely affected by the emergence of the
antimicrobial resistance phenomenon, leading to increased morbidity and mortality …