Cellular and molecular mechanisms of autoimmune hepatitis

GJ Webb, GM Hirschfield, EL Krawitt… - Annual Review of …, 2018 - annualreviews.org
Autoimmune hepatitis is an uncommon idiopathic syndrome of immune-mediated
destruction of hepatocytes, typically associated with autoantibodies. The disease etiology is …

Aetiopathogenesis of autoimmune hepatitis

MS Longhi, Y Ma, G Mieli-Vergani, D Vergani - Journal of autoimmunity, 2010 - Elsevier
Interface hepatitis, histological hallmark of autoimmune hepatitis (AIH), is a dense portal
mononuclear cell infiltrate invading the parenchyma, consisting of CD4 and CD8 T …

Identification of hepatitis A virus as a trigger for autoimmune chronic hepatitis type 1 in susceptible individuals

S Vento, T Garofano, L Dolci, G Di Perri, E Concia… - The Lancet, 1991 - Elsevier
To identify factors contributing to the pathogenesis of autoimmune chronic active hepatitis
(CAH) healthy relatives of 13 patients with the disorder were followed prospectively for 4 …

Cutting edge issues in autoimmune hepatitis

R Liberal, EL Krawitt, JM Vierling, MP Manns… - Journal of …, 2016 - Elsevier
Autoimmune hepatitis (AIH) is a severe liver disease affecting all age groups worldwide.
Novel basic and clinical aspects of AIH, addressed at a Monothematic Conference in …

Pathogenesis of autoimmune hepatitis

R Liberal, MS Longhi, G Mieli-Vergani… - Best practice & research …, 2011 - Elsevier
The mechanisms underlying the pathogenesis of autoimmune hepatitis are not fully
understood, though there is growing evidence that genetic predisposition, molecular mimicry …

Tacrolimus: a potential new treatment for autoimmune chronic active hepatitis: results of an open-label preliminary trial

DH Van Thiel, H Wright, P Carroll… - … American journal of …, 1995 - pmc.ncbi.nlm.nih.gov
Autoimmune chronic active hepatitis (CAH-A) is a chronic liver disease of unknown etiology
that is believed to have an autoimmune pathogenesis. The disease is slowly progressive …

Autoimmune hepatitis

G Mieli-Vergani, D Vergani - Nature Reviews Gastroenterology & …, 2011 - nature.com
Autoimmune hepatitis (AIH) is an inflammatory liver disease that mainly affects females. It is
characterized histologically by interface hepatitis, biochemically by increased aspartate and …

Pathogenesis of autoimmune hepatitis

D Vergani, K Choudhuri, DP Bogdanos… - Clinics in liver …, 2002 - liver.theclinics.com
Pathogenesis, which is defined as the process leading to disease, involves a continuous
interaction between genetic and environmental factors. These factors have been widely …

Autoimmune hepatitis: a review of current diagnosis and treatment

A Makol, KD Watt… - Hepatitis research and …, 2011 - Wiley Online Library
Autoimmune hepatitis (AIH) is a chronic inflammatory disorder characterized by periportal
inflammation, elevated immunoglobulins, autoantibodies, and a dramatic response to …

Immunohistochemical features of the portal tract mononuclear cell infiltrate in chronic aggressive hepatitis.

G Senaldi, B Portmann, AP Mowat… - Archives of disease in …, 1992 - adc.bmj.com
The portal tract mononuclear cell infiltrate has been characterised in 28 liver biopsy samples
showing features of chronic aggressive hepatitis from 12 patients with autoimmune chronic …