Ryanodine receptors: structure, expression, molecular details, and function in calcium release
JT Lanner, DK Georgiou, AD Joshi… - Cold Spring Harbor …, 2010 - cshperspectives.cshlp.org
Ryanodine receptors (RyRs) are located in the sarcoplasmic/endoplasmic reticulum
membrane and are responsible for the release of Ca2+ from intracellular stores during …
membrane and are responsible for the release of Ca2+ from intracellular stores during …
Physiology and pathology of calcium signaling in the brain
Calcium (Ca2+) plays fundamental and diversified roles in neuronal plasticity. As second
messenger of many signaling pathways, Ca2+ as been shown to regulate neuronal gene …
messenger of many signaling pathways, Ca2+ as been shown to regulate neuronal gene …
Modulation of cardiac ryanodine receptor 2 by calmodulin
The high-conductance intracellular calcium (Ca2+) channel RyR2 is essential for the
coupling of excitation and contraction in cardiac muscle. Among various modulators …
coupling of excitation and contraction in cardiac muscle. Among various modulators …
[HTML][HTML] RyR1 S-nitrosylation underlies environmental heat stroke and sudden death in Y522S RyR1 knockin mice
WJ Durham, P Aracena-Parks, C Long, AE Rossi… - Cell, 2008 - cell.com
Mice with a malignant hyperthermia mutation (Y522S) in the ryanodine receptor (RyR1)
display muscle contractures, rhabdomyolysis, and death in response to elevated …
display muscle contractures, rhabdomyolysis, and death in response to elevated …
Calmodulin as an ion channel subunit
Y Saimi, C Kung - Annual review of physiology, 2002 - annualreviews.org
▪ Abstract A surprising variety of ion channels found in a wide range of species from Homo to
Paramecium use calmodulin (CaM) as their constitutive or dissociable Ca2+-sensing …
Paramecium use calmodulin (CaM) as their constitutive or dissociable Ca2+-sensing …
Calcium, calmodulin, and calcium-calmodulin kinase II: heartbeat to heartbeat and beyond
LS Maier and DM Bers. Calcium, Calmodulin, and Calcium-Calmodulin Kinase II: Heartbeat
to Heartbeat and Beyond. Journal of Molecular and Cellular Cardiology (2002) 34, 919–939 …
to Heartbeat and Beyond. Journal of Molecular and Cellular Cardiology (2002) 34, 919–939 …
Macromolecular complexes regulating cardiac ryanodine receptor function
DM Bers - Journal of molecular and cellular cardiology, 2004 - Elsevier
The cardiac ryanodine receptor (RyR) is the sarcoplasmic reticulum (SR) Ca-release
channel which is centrally involved in the myocyte excitation–contraction (E–C) coupling …
channel which is centrally involved in the myocyte excitation–contraction (E–C) coupling …
Calmodulin binding and inhibition of cardiac muscle calcium release channel (ryanodine receptor)
Metabolically 35 S-labeled calmodulin (CaM) was used to determine the CaM binding
properties of the cardiac ryanodine receptor (RyR2) and to identify potential channel …
properties of the cardiac ryanodine receptor (RyR2) and to identify potential channel …
Skeletal muscle-specific T-tubule protein STAC3 mediates voltage-induced Ca2+ release and contractility
BR Nelson, F Wu, Y Liu, DM Anderson… - Proceedings of the …, 2013 - National Acad Sciences
Excitation–contraction (EC) coupling comprises events in muscle that convert electrical
signals to Ca2+ transients, which then trigger contraction of the sarcomere. Defects in these …
signals to Ca2+ transients, which then trigger contraction of the sarcomere. Defects in these …
Differential modulation of Cav2.1 channels by calmodulin and Ca2+-binding protein 1
A Lee, RE Westenbroek, F Haeseleer… - Nature …, 2002 - nature.com
Abstract Cav2. 1 channels, which mediate P/Q-type Ca2+ currents, undergo
Ca2+/calmodulin (CaM)-dependent inactivation and facilitation that can significantly alter …
Ca2+/calmodulin (CaM)-dependent inactivation and facilitation that can significantly alter …