Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases

JS Loh, WQ Mak, LKS Tan, CX Ng, HH Chan… - Signal transduction and …, 2024 - nature.com
The human gastrointestinal tract is populated with a diverse microbial community. The vast
genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every …

Microbiota-gut-brain axis: Relationships among the vagus nerve, gut microbiota, obesity, and diabetes

S Longo, S Rizza, M Federici - Acta diabetologica, 2023 - Springer
Aims The purpose of this review is to explore the interconnected pathways of the microbiota-
gut-brain axis (MGBA), focusing on the roles of the vagus nerve and glucagon like peptide-1 …

Targeting the gut microbiota-related metabolites for osteoporosis: The inextricable connection of gut-bone axis

YW Zhang, Y Wu, XF Liu, X Chen, JC Su - Ageing research reviews, 2024 - Elsevier
Osteoporosis is a systemic skeletal disease characterized by decreased bone mass,
destruction of bone microstructure, raised bone fragility, and enhanced risk of fractures. The …

Effects of exercise on gut microbiota of adults: a systematic review and Meta-analysis

L Min, A Ablitip, R Wang, T Luciana, M Wei, X Ma - Nutrients, 2024 - mdpi.com
Background: The equilibrium between gut microbiota (GM) and the host plays a pivotal role
in maintaining overall health, influencing various physiological and metabolic functions …

Gut microbiota-host lipid crosstalk in Alzheimer's disease: implications for disease progression and therapeutics

YX Luo, LL Yang, XQ Yao - Molecular Neurodegeneration, 2024 - Springer
Trillions of intestinal bacteria in the human body undergo dynamic transformations in
response to physiological and pathological changes. Alterations in their composition and …

Physical activity and lifestyle modifications in the treatment of neurodegenerative diseases

JA Santiago, JA Potashkin - Frontiers in Aging Neuroscience, 2023 - frontiersin.org
Neurodegenerative diseases have reached alarming numbers in the past decade.
Unfortunately, clinical trials testing potential therapeutics have proven futile. In the absence …

Modulation of the gut microbiota by nutrition and its relationship to epigenetics

K Ferenc, A Sokal-Dembowska, K Helma… - International Journal of …, 2024 - mdpi.com
The intestinal microbiota is a community of microorganisms inhabiting the human intestines,
potentially influencing both physiological and pathophysiological processes in the human …

A systematic framework for understanding the microbiome in human health and disease: from basic principles to clinical translation

Z Ma, T Zuo, N Frey, AY Rangrez - Signal Transduction and Targeted …, 2024 - nature.com
The human microbiome is a complex and dynamic system that plays important roles in
human health and disease. However, there remain limitations and theoretical gaps in our …

Orexin neurons mediate temptation-resistant voluntary exercise

AL Tesmer, X Li, E Bracey, C Schmandt… - Nature …, 2024 - nature.com
Despite the well-known health benefits of physical activity, many people underexercise;
what drives the prioritization of exercise over alternative options is unclear. We developed a …

Exerkines and cardiometabolic benefits of exercise: from bench to clinic

L **, C Diaz-Canestro, Y Wang, MA Tse… - EMBO Molecular …, 2024 - embopress.org
Regular exercise has both immediate and long-lasting benefits on cardiometabolic health,
and has been recommended as a cornerstone of treatment in the management of diabetes …