More than one-third of the worldwide population is overweight or obese and therefore at risk
of develo** type 2 diabetes mellitus. In order to mitigate this pandemic, safer and more …

The common fruit fly, Drosophila melanogaster, is a well studied and highly tractable genetic
model organism for understanding molecular mechanisms of human diseases. Many basic …

The diversity of cell types and regulatory states in the brain, and how these change during
aging, remains largely unknown. We present a single-cell transcriptome atlas of the entire …

The symbiotic microbiota profoundly affect many aspects of host physiology; however, the
molecular mechanisms underlying host-microbe cross-talk are largely unknown. Here, we …

In mammals, the insulin receptor (IR) gene has acquired an additional exon, exon 11. This
exon may be skipped in a developmental and tissue-specific manner. The IR, therefore …

Reduced signaling of insulin-like peptides increases the life-span of nematodes, flies, and
rodents. In the nematode and the fly, secondary hormones downstream of insulin-like …

The relative insufficiency of insulin secretion and/or insulin action causes diabetes.
However, obesity and type 2 diabetes mellitus can be associated with an absolute increase …

In Drosophila melanogaster, ageing is slowed when insulin-like signalling is reduced: life
expectancy is extended by more than 50% when the insulin-like receptor (InR) or its receptor …

Insulin has functions in the brain and dysregulation of these functions may contribute to the
expression of late-life neurodegenerative disease. We provide a brief summary of research …

This review focuses on neuropeptides and peptide hormones, the largest and most diverse
class of neuroactive substances, known in Drosophila and other animals to play roles in …