Liver fibrosis resulting from chronic liver injury can progress to cirrhosis and liver failure.
Current treatments are limited, creating an urgent need for novel antifibrotic therapies …

End-stage organ failure can result from various preexisting conditions and occurs in patients
of all ages, and organ transplantation remains its only treatment. In recent years, extensive …

Humans and other animals produce a diverse collection of antibodies, many of which bind to
carbohydrate chains, referred to as glycans. These anti-glycan antibodies are a critical part …

The shortage of organs for transplantation emphasizes the urgent need for alternative
solutions. Xenotransplantation has emerged as a promising option due to the greater …

The inner structures of the eye are protected by the cornea, which is a transparent
membrane exposed to the external environment and subjected to the risk of lesions and …

Corneal opacity is a leading cause of vision impairment and suffering worldwide.
Transplantation can effectively restore vision and reduce chronic discomfort. However, there …

There is an increasing demand to not only accelerate the development of advanced therapy
tissue engineered medicines, but to also eliminate xenogeneic materials from their …

Organ transplant is a crucial therapeutic strategy offering a life‐saving and transformative
medical intervention. It provides an opportunity to improve their quality of life and increase …

Genome editing in pigs for xenotransplantation has seen significant advances in recent
years. This study compared three methodologies to generate gene-edited embryos …

Orthotopic liver transplantation (OLT) currently serves as the sole definitive treatment for
thousands of patients suffering from end-stage liver disease; and the existing supply of …