Mechanisms underlying spindle assembly and robustness
The microtubule-based spindle orchestrates chromosome segregation during cell division.
Following more than a century of study, many components and pathways contributing to …
Following more than a century of study, many components and pathways contributing to …
Prime movers: the mechanochemistry of mitotic kinesins
Mitotic spindles are self-organizing protein machines that harness teams of multiple force
generators to drive chromosome segregation. Kinesins are key members of these force …
generators to drive chromosome segregation. Kinesins are key members of these force …
Mechanobiology of the mitotic spindle
The mitotic spindle is a microtubule-based assembly that separates the chromosomes
during cell division. As the spindle is basically a mechanical micro machine, the …
during cell division. As the spindle is basically a mechanical micro machine, the …
Human kinesin-5 KIF11 drives the helical motion of anti-parallel and parallel microtubules around each other
During mitosis, motor proteins and microtubule-associated protein organize the spindle
apparatus by cross-linking and sliding microtubules. Kinesin-5 plays a vital role in spindle …
apparatus by cross-linking and sliding microtubules. Kinesin-5 plays a vital role in spindle …
The mitotic spindle is chiral due to torques within microtubule bundles
Mitosis relies on forces generated in the spindle, a micro-machine composed of
microtubules and associated proteins. Forces are required for the congression of …
microtubules and associated proteins. Forces are required for the congression of …
Comparison of actin-and microtubule-based motility systems for application in functional nanodevices
Over the last 25 years, extensive progress has been made in develo** a range of
nanotechnological applications where cytoskeletal filaments and molecular motors are key …
nanotechnological applications where cytoskeletal filaments and molecular motors are key …
3D motion of vesicles along microtubules helps them to circumvent obstacles in cells
I Verdeny-Vilanova, F Wehnekamp… - Journal of cell …, 2017 - journals.biologists.com
Vesicle transport is regulated at multiple levels, including regulation by scaffolding proteins
and the cytoskeleton. This tight regulation is essential, since slowing or stoppage of …
and the cytoskeleton. This tight regulation is essential, since slowing or stoppage of …
Bidirectional helical motility of cytoplasmic dynein around microtubules
Cytoplasmic dynein is a molecular motor responsible for minus-end-directed cargo transport
along microtubules (MTs). Dynein motility has previously been studied on surface …
along microtubules (MTs). Dynein motility has previously been studied on surface …
Directionally biased sidestep** of Kip3/kinesin-8 is regulated by ATP waiting time and motor–microtubule interaction strength
Kinesin-8 motors, which move in a highly processive manner toward microtubule plus ends
where they act as depolymerases, are essential regulators of microtubule dynamics in cells …
where they act as depolymerases, are essential regulators of microtubule dynamics in cells …
Kinesin-14 motors drive a right-handed helical motion of antiparallel microtubules around each other
Within the mitotic spindle, kinesin motors cross-link and slide overlap** microtubules.
Some of these motors exhibit off-axis power strokes, but their impact on motility and force …
Some of these motors exhibit off-axis power strokes, but their impact on motility and force …