The microtubule-based spindle orchestrates chromosome segregation during cell division.
Following more than a century of study, many components and pathways contributing to …

Mitotic spindles are self-organizing protein machines that harness teams of multiple force
generators to drive chromosome segregation. Kinesins are key members of these force …

Microtubule motors play key roles in cellular functions, such as transport, mitosis and cell
motility. Fueled by ATP hydrolysis, they convert chemical energy into mechanical work …

The mitotic spindle is a microtubule-based assembly that separates the chromosomes
during cell division. As the spindle is basically a mechanical micro machine, the …

Mitosis relies on forces generated in the spindle, a micro-machine composed of
microtubules and associated proteins. Forces are required for the congression of …

During mitosis, motor proteins and microtubule-associated protein organize the spindle
apparatus by cross-linking and sliding microtubules. Kinesin-5 plays a vital role in spindle …

Within the mitotic spindle, kinesin motors cross-link and slide overlap** microtubules.
Some of these motors exhibit off-axis power strokes, but their impact on motility and force …

Cytoplasmic dynein is a molecular motor responsible for minus-end-directed cargo transport
along microtubules (MTs). Dynein motility has previously been studied on surface …

Vesicle transport is regulated at multiple levels, including regulation by scaffolding proteins
and the cytoskeleton. This tight regulation is essential, since slowing or stoppage of …

The neck-linker is a structurally conserved region among most members of the kinesin
superfamily of molecular motor proteins that is critical for kinesin's processive transport of …