Organoids/organs-on-a-chip open up new frontiers for basic and clinical research of
intestinal diseases. Species-specific differences hinder research on animal models, while …

Human organoids-on-chips (OrgOCs) are the synergism of human organoids (HOs)
technology and microfluidic organs-on-chips (OOCs). OOCs can mimic extrinsic …

Organoids and cells in organ‐on‐chip platforms replicate higher‐level anatomical,
physiological, or pathological states of tissues and organs. These technologies are widely …

The inefficiency of existing animal models to precisely predict human pharmacological
effects is the root reason for drug development failure. Microphysiological system/organ-on …

Environmental enteric dysfunction (EED) is a subclinical syndrome of intestinal
inflammation, malabsorption and barrier disruption that is highly prevalent in low-and middle …

Alterations in intestinal structure, mechanics and physiology underlie acute and chronic
intestinal conditions, many of which are influenced by dysregulation of microbiome …

Laboratory studies of host–microbe interactions have historically been carried out using
transformed cell lines and animal models. Although much has been learned from these …

Abstract Background Environmental Enteric Dysfunction (EED) is an acquired disorder of
asymptomatic altered gut function, the etiology of which is unknown. EED is postulated to be …

Human organs‐on‐chips (organ chips) are small microfluidic devices that allow human cells
to perform complex organ‐level functions in vitro by recreating multi‐cellular and multi …

Background Sulfadoxine-pyrimethamine (SP) antimalarial therapy has been suggested to
potentially increase the birth weight of infants in pregnant women in sub-Saharan Africa …