The human body contains several hundred cell types, all of which share the same genome.
In metazoans, much of the regulatory code that drives cell type-specific gene expression is …

Chromatin accessibility, or the physical access to chromatinized DNA, is a widely studied
characteristic of the eukaryotic genome. As active regulatory DNA elements are generally …

Enhancers are distal cis-regulatory elements that activate the transcription of their target
genes. They regulate a wide range of important biological functions and processes …

Although enhancers play critical roles in cancer, quantifying enhancer activities in clinical
samples remains challenging, especially for super-enhancers. Enhancer activities can be …

Chromatin accessibility plays a fundamental role in gene regulation. Nucleosome
placement, usually measured by quantifying protection of DNA from enzymatic digestion …

Recent advancements in next-generation sequencing technologies and accompanying
reductions in cost have led to an explosion of techniques to examine DNA accessibility and …

Chromatin accessibility, a crucial component of genome regulation, has primarily been
studied in homogeneous and simple systems, such as isolated cell populations or early …

The pluripotent state of embryonic stem cells (ESCs) is defined by its transcriptome and
epigenome. The chromatin reader Brd4 determines ESC identity. Although Brd4 regulation …