Fungi exhibit an enormous variety of morphologies, including yeast colonies, hyphal
mycelia, and elaborate fruiting bodies. This diversity arises through a combination of polar …

Introduction Cells that simultaneously secrete and sense the same signaling molecule are
ubiquitous. Bacteria sense a quorum by secreting and sensing an autoinducer; T cells …

A rigorous understanding of how multicellular behaviors arise from the actions of single cells
requires quantitative frameworks that bridge the gap between genetic circuits, the …

Cell pairing is central for many processes, including immune defense, neuronal connection,
hyphal fusion, and sexual reproduction. How does a cell orient toward a partner, especially …

Cell signaling systems sense and respond to ligands that bind cell surface receptors. These
systems often respond to changes in the concentration of extracellular ligand more rapidly …

Animals are known to adjust their sexual behaviour depending on mate competition. Here
we report similar regulation for mating behaviour in a sexual unicellular eukaryote, the …

How cells reliably infer information about their environment is a fundamentally important
question. While sensing and signaling generally start with cell-surface receptors, the degree …

Yeast decode pheromone gradients to locate mating partners, providing a model for
chemotropism. How yeast polarize toward a single partner in crowded environments is …

Communication between cells is a ubiquitous feature of cell populations and is frequently
realized by secretion and detection of signaling molecules. Direct visualization of the …

Many biological processes are initiated when diffusing extracellular reactants reach
receptors on a cell membrane. Calculating this arrival rate has therefore attracted theoretical …