Pathological angiogenesis: mechanisms and therapeutic strategies

AC Dudley, AW Griffioen - Angiogenesis, 2023 - Springer
In multicellular organisms, angiogenesis, the formation of new blood vessels from pre-
existing ones, is an essential process for growth and development. Different mechanisms …

Endothelial activation and dysfunction in COVID-19: from basic mechanisms to potential therapeutic approaches

Y **, W Ji, H Yang, S Chen, W Zhang… - Signal transduction and …, 2020 - nature.com
On 12 March 2020, the outbreak of coronavirus disease 2019 (COVID-19) was declared a
pandemic by the World Health Organization. As of 4 August 2020, more than 18 million …

Endothelial dysfunction and altered endothelial biomarkers in patients with post-COVID-19 syndrome and chronic fatigue syndrome (ME/CFS)

M Haffke, H Freitag, G Rudolf, M Seifert… - Journal of Translational …, 2022 - Springer
Background Fatigue, exertion intolerance and post-exertional malaise are among the most
frequent symptoms of Post-COVID Syndrome (PCS), with a subset of patients fulfilling …

Lessons learned 1 year after SARS-CoV-2 emergence leading to COVID-19 pandemic

KKW To, S Sridhar, KHY Chiu, DLL Hung… - Emerging microbes & …, 2021 - Taylor & Francis
Without modern medical management and vaccines, the severity of the Coronavirus
Disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome (SARS) …

The coagulopathy, endotheliopathy, and vasculitis of COVID-19

T Iba, JM Connors, JH Levy - Inflammation Research, 2020 - Springer
Abstract Background COVID-19-associated coagulopathy (CAC) characterized by the
elevated D-dimer without remarkable changes of other global coagulation markers is …

Microvascular dysfunction in COVID-19: the MYSTIC study

A Rovas, I Osiaevi, K Buscher, J Sackarnd… - Angiogenesis, 2021 - Springer
Rationale Pre-clinical and autopsy studies have fueled the hypothesis that a dysregulated
vascular endothelium might play a central role in the pathogenesis of ARDS and multi-organ …

COVID-19 is a systemic vascular hemopathy: insight for mechanistic and clinical aspects

DM Smadja, SJ Mentzer, M Fontenay, MA Laffan… - Angiogenesis, 2021 - Springer
Abstract Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) is presenting as a systemic disease associated with …

Endothelium infection and dysregulation by SARS-CoV-2: evidence and caveats in COVID-19

I Bernard, D Limonta, LK Mahal, TC Hobman - Viruses, 2020 - mdpi.com
The ongoing pandemic of coronavirus disease 2019 (COVID-19) caused by the acute
respiratory syndrome-coronavirus-2 (SARS-CoV-2) poses a persistent threat to global public …

Vasculopathy in COVID-19

R Flaumenhaft, K Enjyoji… - Blood, The Journal of the …, 2022 - ashpublications.org
COVID-19 is a primary respiratory illness that is frequently complicated by systemic
involvement of the vasculature. Vascular involvement leads to an array of complications …

Endothelial damage in acute respiratory distress syndrome

AG Vassiliou, A Kotanidou, I Dimopoulou… - International journal of …, 2020 - mdpi.com
The pulmonary endothelium is a metabolically active continuous monolayer of squamous
endothelial cells that internally lines blood vessels and mediates key processes involved in …