In addition to being valuable source of energy, carbohydrates, one of the main dietary
components, are integral parts of the cell. As extra-& intracellular molecules they act as cell …

Carbohydrates, one of the most abundant classes of biomolecules, are the structural
building blocks of genetic materials and vital source of energy. They are integral part of the …

A series of 2-sulfanyl-6-methyl-1, 4-dihydropyrimidines (8–21) were synthesized in good
yields by alkylation of 5-methyl-6-phenyl-2-thioxo-1, 2, 3, 6-tetrahydropyrimidine-4 …

Control of human filarial infections currently depends on chemotherapeutic strategies
predominantly directed at microfilariae. Doxycycline therapy in an extended daily dose …

New Ni (II) thiosemicarbazone complexes containing triphenylphosphine namely [Ni (Sal-
mtsc)(PPh3)](2) and [Ni (Nap-mtsc)(PPh3)](3)(where Sal-mtsc= salicylaldehyde-N (4) …

Infection with filarial nematodes remains endemic in several countries worldwide and some
of these infections are commonly associated with severe disease. The elimination of …

Lymphatic filariasis, onchocerciasis and loiasis caused by human filarial nematodes are
diseases of tropical and subtropical countries causing considerable morbidity. The available …

A series of 4-oxycoumarin derivatives was synthesized, characterized and evaluated in vitro
and in vivo for antifilarial activity against the human lymphatic filarial parasite, Brugia malayi …

A series of 3-chloro-4-substituted-1-(8-hydroxy-quinolin-5-yl)-azetidin-2-ones were
synthesized and evaluated for their in vitro anti-filarial activity. To pre-assess the anti-filarial …

Dihydrofolate reductase (DHFR) is a well-known target for antibacterial and anticancer
therapy. DHFR inhibitors are useful for protozoan parasites, but are yet to be explored …