Viewing metabolism through the lens of exercise biology has proven an accessible and
practical strategy to gain new insights into local and systemic metabolic regulation. Recent …

Mitochondria are key determinants of cellular health. However, the functional role of
mitochondria varies from cell to cell depending on the relative demands for energy …

Calcium is believed to regulate mitochondrial oxidative phosphorylation, thereby
contributing to the maintenance of cellular energy homeostasis. Skeletal muscle, with an …

During high-intensity submaximal exercise, muscle fatigue and decreased efficiency are
intertwined closely, and each contributes to exercise intolerance. Fatigue and muscle …

The design of the energy metabolism system in striated muscle remains a major area of
investigation. Here, we review our current understanding and emerging hypotheses …

Aim Calcium ions play a pivotal role in matching energy supply and demand in cardiac
muscle. Mitochondrial calcium concentration is lower in animal models of heart failure with …

Magnetic resonance spectroscopy (MRS) can give information about cellular metabolism in
vivo which is difficult to obtain in other ways. In skeletal muscle, non‐invasive 31 P MRS …

The parameters of the power-duration relationship for severe-intensity exercise (ie, the
critical power (CP) and the curvature constant (W′)) are related to the kinetics of pulmonary …

The observation that prior heavy or severe-intensity exercise speeds overall oxygen uptake
(V˙ O2) kinetics, termed the “priming effect”, has garnered significant research attention and …

Key points Heavy‐intensity exercise causes a progressive increase in energy demand that
contributes to exercise limitation. This inefficiency arises within the locomotor muscles and is …