The origin and diversification of mitochondria
Mitochondria are best known for their role in the generation of ATP by aerobic respiration.
Yet, research in the past half century has shown that they perform a much larger suite of …
Yet, research in the past half century has shown that they perform a much larger suite of …
Mechanisms of mitochondrial iron-sulfur protein biogenesis
R Lill, SA Freibert - Annual review of biochemistry, 2020 - annualreviews.org
Mitochondria are essential in most eukaryotes and are involved in numerous biological
functions including ATP production, cofactor biosyntheses, apoptosis, lipid synthesis, and …
functions including ATP production, cofactor biosyntheses, apoptosis, lipid synthesis, and …
Functional spectrum and specificity of mitochondrial ferredoxins FDX1 and FDX2
V Schulz, S Basu, SA Freibert, H Webert, L Boss… - Nature chemical …, 2023 - nature.com
Ferredoxins comprise a large family of iron–sulfur (Fe–S) proteins that shuttle electrons in
diverse biological processes. Human mitochondria contain two isoforms of [2Fe-2S] …
diverse biological processes. Human mitochondria contain two isoforms of [2Fe-2S] …
[HTML][HTML] Mechanistic concepts of iron-sulfur protein biogenesis in Biology
JJ Braymer, SA Freibert, M Rakwalska-Bange… - Biochimica et Biophysica …, 2021 - Elsevier
Abstract Iron-sulfur (Fe/S) proteins are present in virtually all living organisms and are
involved in numerous cellular processes such as respiration, photosynthesis, metabolic …
involved in numerous cellular processes such as respiration, photosynthesis, metabolic …
Iron–sulfur cluster biogenesis and trafficking in mitochondria
JJ Braymer, R Lill - Journal of Biological Chemistry, 2017 - ASBMB
The biogenesis of iron–sulfur (Fe/S) proteins in eukaryotes is a multistage,
multicompartment process that is essential for a broad range of cellular functions, including …
multicompartment process that is essential for a broad range of cellular functions, including …
FDX1 regulates cellular protein lipoylation through direct binding to LIAS
Ferredoxins are a family of iron–sulfur (Fe-S) cluster proteins that serve as essential electron
donors in numerous cellular processes that are conserved through evolution. The …
donors in numerous cellular processes that are conserved through evolution. The …
Physiologically relevant reconstitution of iron-sulfur cluster biosynthesis uncovers persulfide-processing functions of ferredoxin-2 and frataxin
S Gervason, D Larkem, AB Mansour… - Nature …, 2019 - nature.com
Abstract Iron-sulfur (Fe-S) clusters are essential protein cofactors whose biosynthetic defects
lead to severe diseases among which is Friedreich's ataxia caused by impaired expression …
lead to severe diseases among which is Friedreich's ataxia caused by impaired expression …
Cytonuclear integration and co-evolution
The partitioning of genetic material between the nucleus and cytoplasmic (mitochondrial and
plastid) genomes within eukaryotic cells necessitates coordinated integration between these …
plastid) genomes within eukaryotic cells necessitates coordinated integration between these …
Structure and functional dynamics of the mitochondrial Fe/S cluster synthesis complex
Abstract Iron–sulfur (Fe/S) clusters are essential protein cofactors crucial for many cellular
functions including DNA maintenance, protein translation, and energy conversion. De novo …
functions including DNA maintenance, protein translation, and energy conversion. De novo …
[HTML][HTML] METTL17 is an Fe-S cluster checkpoint for mitochondrial translation
Friedreich's ataxia (FA) is a debilitating, multisystemic disease caused by the depletion of
frataxin (FXN), a mitochondrial iron-sulfur (Fe-S) cluster biogenesis factor. To understand the …
frataxin (FXN), a mitochondrial iron-sulfur (Fe-S) cluster biogenesis factor. To understand the …