Starting at the mesoscopic level with a general formulation of stochastic thermodynamics in
terms of Markov jump processes, the scaling conditions that ensure the emergence of a …

Health emerges from coordinated psychobiological processes powered by mitochondrial
energy transformation. But how do mitochondria regulate the multisystem responses that …

Chronic psychosocial stress increases disease risk and mortality, but the underlying
mechanisms remain largely unclear. Here we outline an energy-based model for the …

Patients with primary mitochondrial oxidative phosphorylation (OxPhos) defects present with
fatigue and multi-system disorders, are often lean, and die prematurely, but the mechanistic …

For continuous-time Markov chains and open unimolecular chemical reaction networks, we
prove that any two stationary currents are linearly related upon perturbations of a single …

Although polyploidization is frequent in development, cancer, and evolution, impacts on
animal metabolism are poorly understood. In Xenopus frogs, the number of genome copies …

Temperature changes and periods of detrimental cold occur frequently for many organisms
in their natural habitats. Homeothermic animals have evolved metabolic adaptation …

All life forms depend on the conversion of energy into biomass used in growth and
reproduction. For unicellular heterotrophs, the energetic cost associated with building a cell …

In living systems, irreversible, yet stochastic, molecular interactions form multiscale
structures (such as cytoskeletal networks), which mediate processes (such as cytokinesis …

Aging involves seemingly paradoxical changes in energy metabolism. Molecular damage
accumulation increases cellular energy expenditure, yet whole-body energy expenditure …