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mRNAs, proteins and the emerging principles of gene expression control
Gene expression involves transcription, translation and the turnover of mRNAs and proteins.
The degree to which protein abundances scale with mRNA levels and the implications in …
The degree to which protein abundances scale with mRNA levels and the implications in …
Promoter-proximal pausing of RNA polymerase II: a nexus of gene regulation
Precise spatio–temporal control of gene activity is essential for organismal development,
growth, and survival in a changing environment. Decisive steps in gene regulation involve …
growth, and survival in a changing environment. Decisive steps in gene regulation involve …
Transcription shapes 3D chromatin organization by interacting with loop extrusion
Cohesin folds mammalian interphase chromosomes by extruding the chromatin fiber into
numerous loops.“Loop extrusion” can be impeded by chromatin-bound factors, such as …
numerous loops.“Loop extrusion” can be impeded by chromatin-bound factors, such as …
Mediator and RNA polymerase II clusters associate in transcription-dependent condensates
Models of gene control have emerged from genetic and biochemical studies, with limited
consideration of the spatial organization and dynamics of key components in living cells. We …
consideration of the spatial organization and dynamics of key components in living cells. We …
Imaging dynamic and selective low-complexity domain interactions that control gene transcription
INTRODUCTION DNA binding transcription factors (TFs) are quintessential regulators of
eukaryotic gene expression. Early studies of TFs revealed their well-structured DNA binding …
eukaryotic gene expression. Early studies of TFs revealed their well-structured DNA binding …
RNA polymerase II clustering through carboxy-terminal domain phase separation
M Boehning, C Dugast-Darzacq, M Rankovic… - Nature structural & …, 2018 - nature.com
The carboxy-terminal domain (CTD) of RNA polymerase (Pol) II is an intrinsically disordered
low-complexity region that is critical for pre-mRNA transcription and processing. The CTD …
low-complexity region that is critical for pre-mRNA transcription and processing. The CTD …
RNA polymerase II speed: a key player in controlling and adapting transcriptome composition
Abstract RNA polymerase II (RNA Pol II) speed or elongation rate, ie, the number of
nucleotides synthesized per unit of time, is a major determinant of transcriptome …
nucleotides synthesized per unit of time, is a major determinant of transcriptome …
Phase-separation mechanism for C-terminal hyperphosphorylation of RNA polymerase II
Hyperphosphorylation of the C-terminal domain (CTD) of the RPB1 subunit of human RNA
polymerase (Pol) II is essential for transcriptional elongation and mRNA processing,–. The …
polymerase (Pol) II is essential for transcriptional elongation and mRNA processing,–. The …
Illuminating RNA biology through imaging
RNA processing plays a central role in accurately transmitting genetic information into
functional RNA and protein regulators. To fully appreciate the RNA life-cycle, tools to …
functional RNA and protein regulators. To fully appreciate the RNA life-cycle, tools to …
Liquid–liquid phase separation in chromatin
In eukaryotic cells, protein and RNA factors involved in genome activities like transcription,
RNA processing, DNA replication, and repair accumulate in self-organizing membraneless …
RNA processing, DNA replication, and repair accumulate in self-organizing membraneless …