Evidence for a lipofibroblast-to-Cthrc1+ myofibroblast reversible switch during the development and resolution of lung fibrosis in young mice
Background Fibrosis is often associated with aberrant repair mechanisms that ultimately
lead to organ failure. In the lung, idiopathic pulmonary fibrosis (IPF) is a fatal form of …
lead to organ failure. In the lung, idiopathic pulmonary fibrosis (IPF) is a fatal form of …
COX Postulates: Remember the Fibroblast
GA FitzGerald - Arteriosclerosis, Thrombosis, and Vascular Biology, 2024 - Am Heart Assoc
Arachidonic acid is a polyunsaturated fatty acid con-stituent of cell membranes, mobilized for
release by activation of phospholipases by diverse physical and chemical stimuli. Its …
release by activation of phospholipases by diverse physical and chemical stimuli. Its …
Impaired AMPK Control of Alveolar Epithelial Cell Metabolism Promotes Pulmonary Fibrosis
Alveolar epithelial type II (AT2) cell dysfunction is implicated in the pathogenesis of familial
and sporadic idiopathic pulmonary fibrosis (IPF). We previously described that expression of …
and sporadic idiopathic pulmonary fibrosis (IPF). We previously described that expression of …
Aberrant Transitional Alveolar Epithelial Cells Promote Pathogenic Activation of Lung Fibroblasts in Preclinical Fibrosis Modeling
Pulmonary fibrosis (PF) is a chronic progressive lung disease histopathologically
characterized by fibrotic remodeling and the presence of pathological epithelial and …
characterized by fibrotic remodeling and the presence of pathological epithelial and …