Transcription regulation networks control the expression of genes. The transcription
networks of well-studied microorganisms appear to be made up of a small set of recurring …

In order to understand the functioning of organisms on the molecular level, we need to know
which genes are expressed, when and where in the organism, and to which extent. The …

RegulonDB, first published 20 years ago, is a comprehensive electronic resource about
regulation of transcription initiation of Escherichia coli K-12 with decades of knowledge from …

Complex networks are studied across many fields of science. To uncover their structural
design principles, we defined “network motifs,” patterns of interconnections occurring in …

Praise for the first edition:… superb, beautifully written and organized work that takes an
engineering approach to systems biology. Alon provides nicely written appendices to …

Little is known about the design principles 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 of transcriptional
regulation networks that control gene expression in cells. Recent advances in data …

Engineered systems are often built of recurring circuit modules that carry out key functions.
Transcription networks that regulate the responses of living cells were recently found to obey …

We have determined how most of the transcriptional regulators encoded in the eukaryote
Saccharomyces cerevisiae associate with genes across the genome in living cells. Just as …

Complex biological, technological, and sociological networks can be of very different sizes
and connectivities, making it difficult to compare their structures. Here we present an …

Stochastic mechanisms are ubiquitous in biological systems. Biochemical reactions that
involve small numbers of molecules are intrinsically noisy, being dominated by large …