Long non-coding RNAs: definitions, functions, challenges and recommendations
Genes specifying long non-coding RNAs (lncRNAs) occupy a large fraction of the genomes
of complex organisms. The term 'lncRNAs' encompasses RNA polymerase I (Pol I), Pol II …
of complex organisms. The term 'lncRNAs' encompasses RNA polymerase I (Pol I), Pol II …
Cellular origins of dsRNA, their recognition and consequences
YG Chen, S Hur - Nature Reviews Molecular Cell Biology, 2022 - nature.com
Double-stranded RNA (dsRNA) is associated with most viral infections—it either constitutes
the viral genome (in the case of dsRNA viruses) or is generated in host cells during viral …
the viral genome (in the case of dsRNA viruses) or is generated in host cells during viral …
Exosome transfer from stromal to breast cancer cells regulates therapy resistance pathways
Stromal communication with cancer cells can influence treatment response. We show that
stromal and breast cancer (BrCa) cells utilize paracrine and juxtacrine signaling to drive …
stromal and breast cancer (BrCa) cells utilize paracrine and juxtacrine signaling to drive …
Tumor stem-like cell-derived exosomal RNAs prime neutrophils for facilitating tumorigenesis of colon cancer
WL Hwang, HY Lan, WC Cheng, SC Huang… - Journal of hematology & …, 2019 - Springer
Background Cell-cell interactions maintain tissue homeostasis and contribute to dynamic
alteration of the tumor microenvironment (TME). Communication between cancer and host …
alteration of the tumor microenvironment (TME). Communication between cancer and host …
RNA polymerase III transcription as a disease factor
RNA polymerase (Pol) III is responsible for transcription of different noncoding genes in
eukaryotic cells, whose RNA products have well-defined functions in translation and other …
eukaryotic cells, whose RNA products have well-defined functions in translation and other …
An old friend with a new face: tRNA-derived small RNAs with big regulatory potential in cancer biology
Transfer RNAs (tRNAs) are small non-coding RNAs (sncRNAs) essential for protein
translation. Emerging evidence suggests that tRNAs can also be processed into smaller …
translation. Emerging evidence suggests that tRNAs can also be processed into smaller …
Pre-ribosomal RNA processing in human cells: from mechanisms to congenital diseases
Ribosomal RNAs, the most abundant cellular RNA species, have evolved as the structural
scaffold and the catalytic center of protein synthesis in every living organism. In eukaryotes …
scaffold and the catalytic center of protein synthesis in every living organism. In eukaryotes …
Transcription by RNA polymerase III: insights into mechanism and regulation
The highly abundant, small stable RNAs that are synthesized by RNA polymerase III
(RNAPIII) have key functional roles, particularly in the protein synthesis apparatus. Their …
(RNAPIII) have key functional roles, particularly in the protein synthesis apparatus. Their …
N6-adenine DNA methylation is associated with the linker DNA of H2A.Z-containing well-positioned nucleosomes in Pol II-transcribed genes in Tetrahymena
Abstract DNA N6-methyladenine (6mA) is newly rediscovered as a potential epigenetic mark
across a more diverse range of eukaryotes than previously realized. As a unicellular model …
across a more diverse range of eukaryotes than previously realized. As a unicellular model …
The nuclear and cytoplasmic activities of RNA polymerase III, and an evolving transcriptome for surveillance
AC Kessler, RJ Maraia - Nucleic Acids Research, 2021 - academic.oup.com
A 1969 report that described biochemical and activity properties of the three eukaryotic RNA
polymerases revealed Pol III as highly distinguishable, even before its transcripts were …
polymerases revealed Pol III as highly distinguishable, even before its transcripts were …