[HTML][HTML] Long non-coding RNAs and exosomal lncRNAs: Potential functions in lung cancer progression, drug resistance and tumor microenvironment remodeling

M Entezari, M Ghanbarirad, A Taheriazam… - Biomedicine & …, 2022 - Elsevier
Among the different kinds of tumors threatening human life, lung cancer is one that is
commonly observed in both males and females. The aggressive behavior of lung cancer …

Polo-like kinase 1 inhibitors in human cancer therapy: development and therapeutic potential

J Zhang, L Zhang, J Wang, L Ouyang… - Journal of medicinal …, 2022 - ACS Publications
Polo-like kinase 1 (PLK1) plays an important role in a variety of cellular functions, including
the regulation of mitosis, DNA replication, autophagy, and the epithelial–mesenchymal …

[HTML][HTML] Advances and challenges in the treatment of lung cancer

Y Li, B Yan, S He - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Lung cancer accounts for a relatively high proportion of malignant tumors. As the most
prevalent type of lung cancer, non-small cell lung cancer (NSCLC) is characterized by high …

Comprehensive review of CRISPR-based gene editing: mechanisms, challenges, and applications in cancer therapy

M Chehelgerdi, M Chehelgerdi… - Molecular cancer, 2024 - Springer
The CRISPR system is a revolutionary genome editing tool that has the potential to
revolutionize the field of cancer research and therapy. The ability to precisely target and edit …

Signaling pathway and small-molecule drug discovery of FGFR: A comprehensive review

J Zheng, W Zhang, L Li, Y He, Y Wei, Y Dang… - Frontiers in …, 2022 - frontiersin.org
Targeted therapy is a groundbreaking innovation for cancer treatment. Among the receptor
tyrosine kinases, the fibroblast growth factor receptors (FGFRs) garnered substantial …

FGFR families: biological functions and therapeutic interventions in tumors

Q Liu, J Huang, W Yan, Z Liu, S Liu, W Fang - MedComm, 2023 - Wiley Online Library
There are five fibroblast growth factor receptors (FGFRs), namely, FGFR1–FGFR5. When
FGFR binds to its ligand, namely, fibroblast growth factor (FGF), it dimerizes and …

Advances in delivery systems for CRISPR/Cas-mediated cancer treatment: a focus on viral vectors and extracellular vesicles

Z Song, Y Tao, Y Liu, J Li - Frontiers in Immunology, 2024 - frontiersin.org
The delivery of CRISPR/Cas systems holds immense potential for revolutionizing cancer
treatment, with recent advancements focusing on extracellular vesicles (EVs) and viral …

Preclinical Anticipation of On-and Off-Target Resistance Mechanisms to Anti-Cancer Drugs: A Systematic Review

PJ Dziubańska-Kusibab, E Nevedomskaya… - International Journal of …, 2024 - mdpi.com
The advent of targeted therapies has led to tremendous improvements in treatment options
and their outcomes in the field of oncology. Yet, many cancers outsmart precision drugs by …

Clinical advances and challenges in targeting FGF/FGFR signaling in lung cancer

M Peng, J Deng, X Li - Molecular Cancer, 2024 - Springer
Fibroblast growth factors (FGFs) and their receptors regulate numerous cellular processes,
such as metabolism and signal transduction, but can also drive tumorigenesis. Specifically …

Synergistic effects of FGFR1 and PLK1 inhibitors target a metabolic liability in KRAS‐mutant cancer

Z Yang, SQ Liang, M Saliakoura, H Yang… - EMBO molecular …, 2021 - embopress.org
KRAS oncoprotein is commonly mutated in human cancer, but effective therapies
specifically targeting KRAS‐driven tumors remain elusive. Here, we show that combined …