[HTML][HTML] Long non-coding RNAs and exosomal lncRNAs: Potential functions in lung cancer progression, drug resistance and tumor microenvironment remodeling
Among the different kinds of tumors threatening human life, lung cancer is one that is
commonly observed in both males and females. The aggressive behavior of lung cancer …
commonly observed in both males and females. The aggressive behavior of lung cancer …
Polo-like kinase 1 inhibitors in human cancer therapy: development and therapeutic potential
Polo-like kinase 1 (PLK1) plays an important role in a variety of cellular functions, including
the regulation of mitosis, DNA replication, autophagy, and the epithelial–mesenchymal …
the regulation of mitosis, DNA replication, autophagy, and the epithelial–mesenchymal …
[HTML][HTML] Advances and challenges in the treatment of lung cancer
Y Li, B Yan, S He - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Lung cancer accounts for a relatively high proportion of malignant tumors. As the most
prevalent type of lung cancer, non-small cell lung cancer (NSCLC) is characterized by high …
prevalent type of lung cancer, non-small cell lung cancer (NSCLC) is characterized by high …
Comprehensive review of CRISPR-based gene editing: mechanisms, challenges, and applications in cancer therapy
M Chehelgerdi, M Chehelgerdi… - Molecular cancer, 2024 - Springer
The CRISPR system is a revolutionary genome editing tool that has the potential to
revolutionize the field of cancer research and therapy. The ability to precisely target and edit …
revolutionize the field of cancer research and therapy. The ability to precisely target and edit …
Signaling pathway and small-molecule drug discovery of FGFR: A comprehensive review
Targeted therapy is a groundbreaking innovation for cancer treatment. Among the receptor
tyrosine kinases, the fibroblast growth factor receptors (FGFRs) garnered substantial …
tyrosine kinases, the fibroblast growth factor receptors (FGFRs) garnered substantial …
FGFR families: biological functions and therapeutic interventions in tumors
Q Liu, J Huang, W Yan, Z Liu, S Liu, W Fang - MedComm, 2023 - Wiley Online Library
There are five fibroblast growth factor receptors (FGFRs), namely, FGFR1–FGFR5. When
FGFR binds to its ligand, namely, fibroblast growth factor (FGF), it dimerizes and …
FGFR binds to its ligand, namely, fibroblast growth factor (FGF), it dimerizes and …
Advances in delivery systems for CRISPR/Cas-mediated cancer treatment: a focus on viral vectors and extracellular vesicles
Z Song, Y Tao, Y Liu, J Li - Frontiers in Immunology, 2024 - frontiersin.org
The delivery of CRISPR/Cas systems holds immense potential for revolutionizing cancer
treatment, with recent advancements focusing on extracellular vesicles (EVs) and viral …
treatment, with recent advancements focusing on extracellular vesicles (EVs) and viral …
Preclinical Anticipation of On-and Off-Target Resistance Mechanisms to Anti-Cancer Drugs: A Systematic Review
PJ Dziubańska-Kusibab, E Nevedomskaya… - International Journal of …, 2024 - mdpi.com
The advent of targeted therapies has led to tremendous improvements in treatment options
and their outcomes in the field of oncology. Yet, many cancers outsmart precision drugs by …
and their outcomes in the field of oncology. Yet, many cancers outsmart precision drugs by …
Clinical advances and challenges in targeting FGF/FGFR signaling in lung cancer
M Peng, J Deng, X Li - Molecular Cancer, 2024 - Springer
Fibroblast growth factors (FGFs) and their receptors regulate numerous cellular processes,
such as metabolism and signal transduction, but can also drive tumorigenesis. Specifically …
such as metabolism and signal transduction, but can also drive tumorigenesis. Specifically …
Synergistic effects of FGFR1 and PLK1 inhibitors target a metabolic liability in KRAS‐mutant cancer
KRAS oncoprotein is commonly mutated in human cancer, but effective therapies
specifically targeting KRAS‐driven tumors remain elusive. Here, we show that combined …
specifically targeting KRAS‐driven tumors remain elusive. Here, we show that combined …