Continuous‐flow technology—a tool for the safe manufacturing of active pharmaceutical ingredients

B Gutmann, D Cantillo… - Angewandte Chemie …, 2015 - Wiley Online Library
In the past few years, continuous‐flow reactors with channel dimensions in the micro‐or
millimeter region have found widespread application in organic synthesis. The characteristic …

Novel process windows for enabling, accelerating, and uplifting flow chemistry

V Hessel, D Kralisch, N Kockmann, T Noël… - …, 2013 - Wiley Online Library
Abstract Novel Process Windows make use of process conditions that are far from
conventional practices. This involves the use of high temperatures, high pressures, high …

Heterogeneous catalytic hydrogenation reactions in continuous‐flow reactors

M Irfan, TN Glasnov, CO Kappe - ChemSusChem, 2011 - Wiley Online Library
Microreactor technology and continuous flow processing in general are key features in
making organic synthesis both more economical and environmentally friendly …

Strecker reaction and α-amino nitriles: Recent advances in their chemistry, synthesis, and biological properties

VV Kouznetsov, CEP Galvis - Tetrahedron, 2018 - Elsevier
Abstract α-Amino nitrile compounds have a profound impact on bio-chemical sciences, as
they have been prepared from inexpensive starting materials and have become valuable …

Continuous flow organic synthesis under high‐temperature/pressure conditions

T Razzaq, CO Kappe - Chemistry–An Asian Journal, 2010 - Wiley Online Library
Microreactor technology and continuous flow processing in general are key features in
making organic synthesis both more economical and environmentally friendly. When …

A flow-microreactor approach to protecting-group-free synthesis using organolithium compounds

H Kim, A Nagaki, J Yoshida - Nature communications, 2011 - nature.com
Protecting-group-free synthesis has received significant recent research interest in the
context of ideal synthesis and green sustainable chemistry. In general, organolithium …

Flow ozonolysis using a semipermeable Teflon AF-2400 membrane to effect gas− liquid contact

M O'Brien, IR Baxendale, SV Ley - Organic letters, 2010 - ACS Publications
Flow Ozonolysis Using a Semipermeable Teflon AF-2400 Membrane To Effect Gas−Liquid
Contact | Organic Letters Recently Viewedclose modal ACS ACS Publications C&EN CAS …

KMnO4-Mediated Oxidation as a Continuous Flow Process

J Sedelmeier, SV Ley, IR Baxendale… - Organic letters, 2010 - ACS Publications
An efficient and easily scalable transformation of alcohols and aldehydes to carboxylic acids
and nitroalkane derivatives to the corresponding carbonyls and carboxylic acids using …

Multistep synthesis using modular flow reactors: Bestmann–Ohira reagent for the formation of alkynes and triazoles

IR Baxendale, SV Ley, AC Mansfield… - Angewandte …, 2009 - Wiley Online Library
In the late 1990s we initiated a research programme to develop methods to assist in the
automation of organic synthesis.[1] While we recognize the flexibility and impressive power …

A flow-based synthesis of Imatinib: the API of Gleevec

MD Hopkin, IR Baxendale, SV Ley - Chemical communications, 2010 - pubs.rsc.org
A concise, flow-based synthesis of Imatinib, a compound used for the treatment of chronic
myeloid leukaemia, is described whereby all steps are conducted in tubular flow coils or …