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Continuous‐flow technology—a tool for the safe manufacturing of active pharmaceutical ingredients
In the past few years, continuous‐flow reactors with channel dimensions in the micro‐or
millimeter region have found widespread application in organic synthesis. The characteristic …
millimeter region have found widespread application in organic synthesis. The characteristic …
Novel process windows for enabling, accelerating, and uplifting flow chemistry
Abstract Novel Process Windows make use of process conditions that are far from
conventional practices. This involves the use of high temperatures, high pressures, high …
conventional practices. This involves the use of high temperatures, high pressures, high …
Heterogeneous catalytic hydrogenation reactions in continuous‐flow reactors
Microreactor technology and continuous flow processing in general are key features in
making organic synthesis both more economical and environmentally friendly …
making organic synthesis both more economical and environmentally friendly …
Strecker reaction and α-amino nitriles: Recent advances in their chemistry, synthesis, and biological properties
VV Kouznetsov, CEP Galvis - Tetrahedron, 2018 - Elsevier
Abstract α-Amino nitrile compounds have a profound impact on bio-chemical sciences, as
they have been prepared from inexpensive starting materials and have become valuable …
they have been prepared from inexpensive starting materials and have become valuable …
Continuous flow organic synthesis under high‐temperature/pressure conditions
Microreactor technology and continuous flow processing in general are key features in
making organic synthesis both more economical and environmentally friendly. When …
making organic synthesis both more economical and environmentally friendly. When …
A flow-microreactor approach to protecting-group-free synthesis using organolithium compounds
H Kim, A Nagaki, J Yoshida - Nature communications, 2011 - nature.com
Protecting-group-free synthesis has received significant recent research interest in the
context of ideal synthesis and green sustainable chemistry. In general, organolithium …
context of ideal synthesis and green sustainable chemistry. In general, organolithium …
Flow ozonolysis using a semipermeable Teflon AF-2400 membrane to effect gas− liquid contact
M O'Brien, IR Baxendale, SV Ley - Organic letters, 2010 - ACS Publications
Flow Ozonolysis Using a Semipermeable Teflon AF-2400 Membrane To Effect Gas−Liquid
Contact | Organic Letters Recently Viewedclose modal ACS ACS Publications C&EN CAS …
Contact | Organic Letters Recently Viewedclose modal ACS ACS Publications C&EN CAS …
KMnO4-Mediated Oxidation as a Continuous Flow Process
J Sedelmeier, SV Ley, IR Baxendale… - Organic letters, 2010 - ACS Publications
An efficient and easily scalable transformation of alcohols and aldehydes to carboxylic acids
and nitroalkane derivatives to the corresponding carbonyls and carboxylic acids using …
and nitroalkane derivatives to the corresponding carbonyls and carboxylic acids using …
Multistep synthesis using modular flow reactors: Bestmann–Ohira reagent for the formation of alkynes and triazoles
IR Baxendale, SV Ley, AC Mansfield… - Angewandte …, 2009 - Wiley Online Library
In the late 1990s we initiated a research programme to develop methods to assist in the
automation of organic synthesis.[1] While we recognize the flexibility and impressive power …
automation of organic synthesis.[1] While we recognize the flexibility and impressive power …
A flow-based synthesis of Imatinib: the API of Gleevec
MD Hopkin, IR Baxendale, SV Ley - Chemical communications, 2010 - pubs.rsc.org
A concise, flow-based synthesis of Imatinib, a compound used for the treatment of chronic
myeloid leukaemia, is described whereby all steps are conducted in tubular flow coils or …
myeloid leukaemia, is described whereby all steps are conducted in tubular flow coils or …