The analysis of polymorphism data is becoming increasingly important as a complementary
tool to classical genetic analyses. Nevertheless, despite plunging sequencing costs …

Patterns of variation and evolution at a given site in a genome can be strongly influenced by
the effects of selection at genetically linked sites. In particular, the recombination rates of …

Progress in defining genomic fitness landscapes in cancer, especially those defined by copy
number alterations (CNAs), has been impeded by lack of time-series single-cell sampling of …

The environmental release of antiviral drugs is of considerable concern due to potential
ecosystem alterations and the development of antiviral resistance. As a result, interest on …

The field of population genomics has grown rapidly in response to the recent advent of
affordable, large-scale sequencing technologies. As opposed to the situation during the …

Natural history collections provide an immense record of biodiversity on Earth. These
repositories have traditionally been used to address fundamental questions in …

The evolutionary dynamics of influenza virus ultimately derive from processes that take
place within and between infected individuals. Here we define influenza virus dynamics in …

Antiviral drug resistance is a matter of great clinical importance that, historically, has been
investigated mostly from a virological perspective. Although the proximate mechanisms of …

Synonymous mutations are often assumed to be neutral with respect to fitness because they
do not alter the encoded amino acid and so cannot be “seen” by natural selection. Yet a …

In rapidly adapting asexual populations, including many microbial pathogens and viruses,
numerous mutant lineages often compete for dominance within the population,,,–. These …