Tryptophanyl-tRNA synthetase (WRS) is an essential enzyme that catalyzes the ligation of
tryptophan (Trp) to its cognate tRNAtrp during translation via aminoacylation. Interestingly …

Publisher Summary This chapter discusses the recent data on higher eukaryotic (mostly
mammalian) aminoacyl-tRNA synthetases (aaRSs) in an attempt to illuminate those features …

A cDNA clone complementary to an interferon (IFN)-induced mRNA was isolated and used
to characterize the regulation of expression of its RNA by the IFNs and to identify the protein …

An interferon gamma (IFN-gamma)-inducible protein, gamma 2, was identified by two-
dimensional gel electrophoresis of transformed human amnion (AMA) cell proteins. cDNA …

The tryptophan (Trp) transport system has a high affinity and selectivity toward Trp, and has
been reported to exist in both human and mouse macrophages. Although this system is …

The purified high molecular weight form of HeLa cell DNA polymerase alpha (
deoxynucleosidetriphosphate: DNA deoxynucleotidyltransferase, EC 2.7. 7.7) was shown to …

A KEY REACTION of the pre-ribosomal stages of protein synthesis is undoubtedly the
aminoacylation of tRNAs, catalysed by aminoacyl-tRNA synthetases. Aminoacyl-tRNA …

Publisher Summary This chapter discusses the role of anticodon in recognition of tRNA by
aminoacyl-tRNA synthetase. The role of the anticodon was studied with both eukaryotic …

The L-tryptophan (Trp) transport system is highly selective for Trp with affinity in the
nanomolar range. This transport system is augmented in human interferon (IFN)-γ-treated …

A full-length cDNA clone encoding the human mitochondrial tryptophanyl-tRNA synthetase
(h mt TrpRS) has been identified. The deduced amino acid sequence shows high homology …