Addictions neuroclinical assessment: a neuroscience-based framework for addictive disorders

LE Kwako, R Momenan, RZ Litten, GF Koob… - Biological …, 2016 - Elsevier
This article proposes a heuristic framework for the Addictions Neuroclinical Assessment that
incorporates key functional domains derived from the neurocircuitry of addiction. We review …

Opiate versus psychostimulant addiction: the differences do matter

A Badiani, D Belin, D Epstein, D Calu… - Nature reviews …, 2011 - nature.com
The publication of the psychomotor stimulant theory of addiction in 1987 and the finding that
addictive drugs increase dopamine concentrations in the rat mesolimbic system in 1988 …

Consumo de alcohol en la adolescencia. Consideraciones médicas y orientaciones educativas

FDR García, MLS Ruiz, RB Alzina - Salud mental, 2014 - medigraphic.com
El consumo de alcohol por parte de los adolescentes supera en España el consumo de
otras sustancias psicoactivas. Los daños que el cerebro humano sufre a causa del etanol …

Behavioral and neuroimaging evidence for overreliance on habit learning in alcohol-dependent patients

Z Sjoerds, S de Wit, W van den Brink… - Translational …, 2013 - nature.com
Substance dependence is characterized by compulsive drug-taking despite negative
consequences. Animal research suggests an underlying imbalance between goal-directed …

Corticotropin releasing factor: a key role in the neurobiology of addiction

EP Zorrilla, ML Logrip, GF Koob - Frontiers in neuroendocrinology, 2014 - Elsevier
Drug addiction is a chronically relapsing disorder characterized by loss of control over intake
and dysregulation of stress-related brain emotional systems. Since the discovery by Wylie …

Compulsivity in obsessive–compulsive disorder and addictions

M Figee, T Pattij, I Willuhn, J Luigjes… - European …, 2016 - Elsevier
Compulsive behaviors are driven by repetitive urges and typically involve the experience of
limited voluntary control over these urges, a diminished ability to delay or inhibit these …

Chronic alcohol neuroadaptation and stress contribute to susceptibility for alcohol craving and relapse

GR Breese, R Sinha, M Heilig - Pharmacology & therapeutics, 2011 - Elsevier
Alcoholism is a chronic relapsing disorder. Major characteristics observed in alcoholics
during an initial period of alcohol abstinence are altered physiological functions and a …

Translational magnetic resonance spectroscopy reveals excessive central glutamate levels during alcohol withdrawal in humans and rats

D Hermann, W Weber-Fahr, A Sartorius, M Hoerst… - Biological …, 2012 - Elsevier
BACKGROUND: In alcoholism, excessive glutamatergic neurotransmission has long been
implicated in the acute withdrawal syndrome and as a key signal for dependence-related …

The role of the central amygdala in alcohol dependence

M Roberto, D Kirson, S Khom - Cold Spring …, 2021 - perspectivesinmedicine.cshlp.org
Alcohol dependence is a chronically relapsing disorder characterized by compulsive drug-
seeking and drug-taking, loss of control in limiting intake, and the emergence of a …

Precision medicine in alcohol dependence: a controlled trial testing pharmacotherapy response among reward and relief drinking phenotypes

K Mann, CR Roos, S Hoffmann, H Nakovics… - …, 2018 - nature.com
Randomized trials of medications for alcohol dependence (AD) often report no differences
between active medications. Few studies in AD have tested hypotheses regarding which …