Tumors are not only aggregates of malignant cells but also well-organized complex
ecosystems. The immunological components within tumors, termed the tumor immune …

Gastric cancer (GC) is one of the most malignant human cancers with increasing incidence
worldwide, ranking among the top five malignant tumors worldwide in terms of incidence …

Advances in cancer biology and sequencing technology have enabled the selection of
targeted and more effective treatments for individual patients with various types of solid …

As an emerging sequencing technology, single-cell RNA sequencing (scRNA-Seq) has
become a powerful tool for describing cell subpopulation classification and cell …

Sequence alterations in microsatellites and an elevated mutational burden are observed in
20% of gastric cancers and associated with clinical response to anti–PD-1 antibodies …

Like most solid tumours, the microenvironment of epithelial-derived gastric adenocarcinoma
(GAC) consists of a variety of stromal cell types, including fibroblasts, and neuronal …

Background & Aims The prognostic value and clinical relevance of tertiary lymphoid
structures (TLSs) in intrahepatic cholangiocarcinoma (iCCA) remain unclear. Thus, we …

Gastric cancer is a major source of global cancer mortality with limited treatment options and
poor patient survival. As our molecular understanding of gastric cancer improves, we are …

Simple Summary Advanced gastric cancer remains a malignancy with a poor prognosis,
with a median survival of about 12–15 months. In recent years, immune checkpoint inhibitors …

Gastric cancer heterogeneity represents a barrier to disease management. We generated a
comprehensive single-cell atlas of gastric cancer (> 200,000 cells) comprising 48 samples …