Parkinson's disease: biomarkers, treatment, and risk factors

FN Emamzadeh, A Surguchov - Frontiers in neuroscience, 2018 - frontiersin.org
Parkinson's disease (PD) is a progressive neurodegenerative disorder caused mainly by
lack of dopamine in the brain. Dopamine is a neurotransmitter involved in movement …

Cellular models of alpha‐synuclein toxicity and aggregation

M Delenclos, JD Burgess… - Journal of …, 2019 - Wiley Online Library
Misfolding and aggregation of alpha‐synuclein (α‐synuclein) with concomitant cytotoxicity is
a hallmark of Lewy body related disorders such as Parkinson's disease, dementia with Lewy …

Mitochondrial damage by α-synuclein causes cell death in human dopaminergic neurons

GK Ganjam, K Bolte, LA Matschke, S Neitemeier… - Cell death & …, 2019 - nature.com
Evolving concepts on Parkinson's disease (PD) pathology suggest that α-synuclein (aSYN)
promote dopaminergic neuron dysfunction and death through accumulating in the …

Exosomal secretion of α-synuclein as protective mechanism after upstream blockage of macroautophagy

N Fussi, M Höllerhage, T Chakroun, NP Nykänen… - Cell death & …, 2018 - nature.com
Accumulation of pathological α-synuclein aggregates plays a major role in Parkinson's
disease. Macroautophagy is a mechanism to degrade intracellular protein aggregates by …

Antiplatelet drugs: potential therapeutic options for the management of neurodegenerative diseases

SK Beura, R Dhapola, AR Panigrahi… - Medicinal Research …, 2023 - Wiley Online Library
The blood platelet plays an important role but often remains under‐recognized in several
vascular complications and associated diseases. Surprisingly, platelet hyperactivity and …

Pharmacological management of dementia with Lewy bodies

LA Hershey, R Coleman-Jackson - Drugs & Aging, 2019 - Springer
Dementia with Lewy bodies (DLB) is a complex disease that involves a variety of cognitive,
behavioral and neurological symptoms, including progressive memory loss, visual …

High-throughput single-cell functional elucidation of neurodevelopmental disease–associated genes reveals convergent mechanisms altering neuronal differentiation

MA Lalli, D Avey, JD Dougherty, J Milbrandt… - Genome …, 2020 - genome.cshlp.org
The overwhelming success of exome-and genome-wide association studies in discovering
thousands of disease-associated genes necessitates develo** novel high-throughput …

Alzheimer's disease and sleep disorders: Insights into the possible disease connections and the potential therapeutic targets

VS Marde, UA Atkare, SV Gawali, PL Tiwari… - Asian Journal of …, 2022 - Elsevier
One of the comorbid conditions in an individual with Alzheimer's disease is a sleep disorder.
Clinical features of sleep disorders involve various sleep disturbances such as Obstructive …

Role of platelet in Parkinson's disease: Insights into pathophysiology & theranostic solutions

SK Beura, AR Panigrahi, P Yadav, SK Singh - Ageing Research Reviews, 2022 - Elsevier
Parkinson's disease (PD) is the second-most-common neurodegenerative disease
characterized by motor and non-motor dysfunctions, which currently affects about 10 million …

[HTML][HTML] From cell lines to pluripotent stem cells for modelling Parkinson's Disease

E Ferrari, A Cardinale, B Picconi, F Gardoni - Journal of Neuroscience …, 2020 - Elsevier
Parkinson's disease (PD) is the second most common neurodegenerative disorder
characterized by loss of dopaminergic (DAergic) neurons in the substantia nigra (SN) that …