The identification of neurological symptoms caused by vitamin A deficiency pointed to a
critical, early developmental role of vitamin A and its metabolite, retinoic acid (RA). The …

The cell-cycle transition from G 1 to S phase has been difficult to visualize. We have
harnessed antiphase oscillating proteins that mark cell-cycle transitions in order to develop …

Recent findings provide evidence for a functional interplay between DNA replication and the
seemingly distinct areas of cancer, development and pluripotency. Protein complexes …

Adult neural stem cells and multiciliated ependymal cells are glial cells essential for
neurological functions. Together, they make up the adult neurogenic niche. Using both high …

Multiciliated cells are abundant in the epithelial surface of different tissues, including cells
lining the walls of the lateral ventricles in the brain and the airway epithelium. Their main …

Multiciliated cells are terminally differentiated, post‐mitotic cells that form hundreds of motile
cilia on their apical surface. Defects in multiciliated cells lead to disease, including …

Neurons are postmitotic cells. Reactivation of the cell cycle by neurons has been reported in
Alzheimer's disease (AD) brains and models. This gave rise to the hypothesis that reentering …

Prereplication complexes (pre-RCs) define potential origins of DNA replication and allow the
recruitment of the replicative DNA helicase MCM2-7. Here, we characterize MCM9, a …

Introduction 3. A role for Cdt1 and Geminin in regulating genomic integrity and cancer
promotion in tumor cells 4. Geminin and Cdt1 as markers for cancer prognosis 5 …

foxD5 is expressed in the nascent neural ectoderm concomitant with several other neural-
fate specifying transcription factors. We used loss-of-function and gain-of-function …